High frequency loss of heterozygosity in the region of the DBH locus in bladder cancer |
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| Authors: | Yang Xiaofeng SHEN Pengfei YAO Kaitai |
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| Institution: | Department of Urology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China;Department of Urology, Xiangya Hospital, Hunan Medical University, Changsha 410078, China;Cancer Research Institute, Hunan Medical University, Changsha 410078, China;Department of Urology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China;Department of Urology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China;Department of Urology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China;Department of Urology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China;Department of Urology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China;Department of Urology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, China |
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| Abstract: | Objective To determine the location of a putative tumor suppressor gene (TSG), and evaluate the frequency loss of heterozygosity (LOH) of the long arm of chromosome 9 (9q) in bladder cancer. Methods We analyzed 25 patients with bladder cancer for LOH of 9q using 25 high-density microsatellite markers. Results Twenty-three samples (92%) showed LOH at least at one locus on 9q. We identified that the commonly deleted region were at 9q12-q21, 9q22, and 9q34. The rate of LOH was 44.0%, 22.7%, 22.7%, 16.0%, 12.0% on DBH, D9S15, D9S1815, D9S1831, D9S176 locus, respectively, and was not significantly related with grades and stages of tumor. Conclusion These data suggest that alteration of a TSG at DBH of 9q may play an important role in the development of bladder cancer. |
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| Keywords: | bladder cancer loss of heterozygosity DBH |
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