| Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance |
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| 作者姓名： | Chen XP DU GH |
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| 作者单位： | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| 摘 要： | Objective To review the recent research progress in lectin-like oxidized low-density lipoprotein receptor-1 （LOX-1） including its protein, ligands, expression and pathophysiological significance. Data sources Information included in this article was identified by searching of PUBMED （1997-2006） online resources using the key term LOX-1. Study selection Mainly original milestone articles and critical reviews written by major pioneer investigators of the field were selected. Results The key issues related to the LOX-1 protein as well as ligands for LOX-1. Factors regulating the expression of LOX-1 were summarized. The pathophysiological functions of LOX-1 in several diseases were discussed. Conclusions Identification of LOX-1 and a definition of its biological role in pathophysiologic states provide deeper insight into the pathogenesis of some cardiovascular diseases especially in atherosclerosis and provide a potential selective therapeutic approach. LOX-1 is unlocking and drugs targeting LOX-1 might be a promising direction to explore.
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| 关 键 词： | 外源凝集素 氧化作用 密度 脂蛋白受体-1 蛋白质 |
| 收稿时间： | 2006-10-08 |
Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance |
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| Chen XP,DU GH.Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance[J].Chinese Medical Journal,2007,120(5):421-426. |
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| Authors: | Chen Xiu-ping DU Guan-hua |
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| Institution: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Objective To review the recent research progress in lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) including its protein, ligands, expression and pathophysiological significance. Data sources Information included in this article was identified by searching of PUBMED (1997-2006) online resources using the key term LOX-1. Study selection Mainly original milestone articles and critical reviews written by major pioneer investigators of the field were selected.Results The key issues related to the LOX-1 protein as well as ligands for LOX-1. Factors regulating the expression of LOX-1 were summarized. The pathophysiological functions of LOX-1 in several diseases were discussed.Conclusions Identification of LOX-1 and a definition of its biological role in pathophysiologic states provide deeper insight into the pathogenesis of some cardiovascular diseases especially in atherosclerosis and provide a potential selective therapeutic approach. LOX-1 is unlocking and drugs targeting LOX-1 might be a promising direction to explore. |
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| Keywords: | scavenger receptors class E oxidized low-density lipoprotein endothelial cells atherosclerosis |
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