| Abstract: | Dimethyll-curine dimethochloride was obtained
by methylating the l-curine which was isolated from
plants belonging to Genesia Cyclea widely distributed
in Hainan Island, South China. It is a non-depolariz-
ing post neuromuscular junctional blocker acting
upon N2 receptor. Its chemical structural formula,
physical properties, pharmacological actions and acute
or chronic toxicities have been thoroughly studied. Its
biological activities varied a great deal in different
experimental animals but their clinical potency is
uniform. Its activity is 51.8% as those of d-tubocura
rine. Clinically, 1,449 cases, male and female, aged
and young, were studied. Among them 422 were
employed for endotracheal intubation, 468 for muscu
Iar relaxation and 559 for both. Operation varied,
including intracraneal, intra-abdominal and open
heart surgery. Different kinds of anesthetics and
adjuvants were used in association. I.V. dosage of
0.4-0.5 mg/kg or more was enough for intubation
while 0.2-0.3 mg/kg for relaxation. Average duration
of action was 30-40 minutes, but could be prolonged
after heavy doses. Side effects were limited only
to mild hypotension and temporal face freshness,
while cardiovascular disturbances were very insig-
nificant. |
