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Association between two polymorphisms of the bone morpho- genetic protein-2 gene with genetic susceptibility to ossification of the posterior longitudinal ligament of the cervical spine and its severity
作者单位:WANG Hao,TIAN Bao-peng(Department of Orthopaedics, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China);YANG Zhao-hui(Departrnent of Orthopaedics, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, China);LIU Dong-mei(Beijing Institute of Neuroscience, Capital Medical University,Beijing Centre of Neural Regeneration and Repair, Key Laboratory of Neurodegenerative Disease of the Ministry of Education,Beijing 100069, China);WANG Ling(Department of Orthopaedic, Health School Clinic Service, Dalian,Liaoning 116001, China);MENG Xiang-long(Department of Orthopaedics, Chaoyang Hospital, Capital MedicalUniversity, Beijing 100020, China) 
基金项目:Basic Research Clinic Foundation of Capital Medical University,No. 2007JL38;
摘    要:Background Ossification of the posterior longitudinal ligament (OPLL) has a strong genetic background. Previous studies have shown that bone morphogenetic protein-2 (BMP2) and BMP2 mRNA are expressed in ossifying matrix and chondrocytes adjacent to cartilaginous areas of OPLL tissues and mesenchymal cells with fibroblastic features in the immediate vicinity of the cartilaginous areas. It is suggested that BMP2 plays different roles in the different stages of development of OPLL. However, it remains unknown which factors induce ligament cells to produce BMP2. Methods OPLL patients (n=-192) and non-OPLL controls (n=304) were studied. Radiographs of the cervical spine were analyzed for extent of OPLL. We investigated whether single nucleotide polymorphisms of exons 3(-726) T/C and 3(-583) NG in the BMP2 gene are statistically associated with genetic susceptibility to OPLL in Chinese Han subjects. Results There was no statistical difference between the occurrence of exons 3(-726) T/C and 3(-583) NG and the occurrence of OPLL in the cervical spine. However, there was a significant association between occurrence of exon 3(-726) T/C polymorphism and occurrence of OPLL in males of cases and controls in the cervical spine. In addition, no significant association was found between the exons 3(-726) T/C and 3(-583) A/G with number of ossified cervical vertebrae in OPLL patients. Conclusions Exon 3(-583) A/G polymorphism in BMP2 gene is not associated with the occurrence and the extent of OPLL in the cervical spine. Chinese Han male patients with TC and CC genotypes in exon 3(-726) T/C have genetic susceptibility to OPLL but not to more extensive OPLL in the cervical spine.

关 键 词:韧带  骨化  颈椎骨  单核苷多态性  骨形态遗传蛋白2

Association between two polymorphisms of the bone morpho- genetic protein-2 gene with genetic susceptibility to ossification of the posterior longitudinal ligament of the cervical spine and its severity
Authors:WANG Hao  YANG Zhao-hui  LIU Dong-mei  WANG Ling  MENG Xiang-long  TIAN Bao-peng
Institution:1. Department of Orthopaedics, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
2. Departrnent of Orthopaedics, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, China
3. Beijing Institute of Neuroscience, Capital Medical University,Beijing Centre of Neural Regeneration and Repair, Key Laboratory of Neurodegenerative Disease of the Ministry of Education,Beijing 100069, China
4. Department of Orthopaedic, Health School Clinic Service, Dalian,Liaoning 116001, China
5. Department of Orthopaedics, Chaoyang Hospital, Capital MedicalUniversity, Beijing 100020, China
Abstract:Background Ossification of the posterior longitudinal ligament (OPLL) has a strong genetic background. Previous studies have shown that bone morphogenetic protein-2 (BMP2) and BMP2 mRNA are expressed in ossifying matrix and chondrocytes adjacent to cartilaginous areas of OPLL tissues and mesenchymal cells with fibroblastic features in the immediate vicinity of the cartilaginous areas. It is suggested that BMP2 plays different roles in the different stages of development of OPLL. However, it remains unknown which factors induce ligament cells to produce BMP2. Methods OPLL patients (n=192) and non-OPLL controls (n=304) were studied. Radiographs of the cervical spine were analyzed for extent of OPLL. We investigated whether single nucleotide polymorphisms of exons 3(-726) T/C and 3(-583) A/G in the BMP2 gene are statistically associated with genetic susceptibility to OPLL in Chinese Han subjects. Results There was no statistical difference between the occurrence of exons 3(-726) T/C and 3(-583) A/G and the occurrence of OPLL in the cervical spine. However, there was a significant association between occurrence of exon 3(-726) T/C polymorphism and occurrence of OPLL in males of cases and controls in the cervical spine. In addition, no significant association was found between the exons 3(-726) T/C and 3(-583) A/G with number of ossified cervical vertebrae in OPLL patients. Conclusions Exon 3(-583) A/G polymorphism in BMP2 gene is not associated with the occurrence and the extent of OPLL in the cervical spine. Chinese Han male patients with TC and CC genotypes in exon 3(-726) T/C have genetic susceptibility to OPLL but not to more extensive OPLL in the cervical spine.
Keywords:ossification of the posterior longitudinal ligament  bone morphogenetic protein-2  single nucleotide polymorphisms  case control study
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