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mass spectrometry Rapid Resolution Liquid Chromatography/Time-of-flight Mass Spectrometry and Mass Profiler Professional
作者姓名:张研  任辉  姜洋  高宇飞  刘淑莹
作者单位:the Second Hospital of Jilin University,the Second Hospital of Jilin University,China-Japan Union Hospital of Jilin University,China-Japan Union Hospital of Jilin University,Changchun institute of applied chemistry
基金项目:grants,from,the,Jilin,Science,and,Technology,Development,Programs(项目编号:200705244,201015071,20090175,20100733,and,201101074)
摘    要:Background Stomach cancer is among the most commonly occurring malignancies worldwide.It would be beneficial to develop a urine-based assay whereby patients with undiagnosed stomach cancer could be scr...

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Urinary metabonomics of stomach cancer assessed by rapid resolution liquid chromatography/time-of-flight mass spectrometry
ZHANG Yan,REN Hui,JIANG Yang,GAO Yu-fei and LIU Shu-ying.mass spectrometry Rapid Resolution Liquid Chromatography/Time-of-flight Mass Spectrometry and Mass Profiler Professional[J].Chinese Medical Journal,2013,126(10):1930-1933.
Authors:ZHANG Yan  REN Hui  JIANG Yang  GAO Yu-fei and LIU Shu-ying
Institution:1. Department of General Surgery, Second Hospital of Jilin University,Changchun, Jilin 130000, China
2. Department of Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China
3. Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China
4. Department of Jilin Ginseng Academy, Changchun University of Chinese Medicine, Jilin 130117, China
Abstract:Background Stomach cancer is among the most commonly occurring malignancies worldwide.It would be beneficial to develop a urine-based assay whereby patients with undiagnosed stomach cancer could be screened and their cancer detected in the earliest stages.Methods A urinary metabonomics method based on ultra-performance liquid chromatography combined with quadruple time-of-flight mass spectrometry was used to analyze urine samples from patients with stomach cancer and healthy controls.Results Statistical analysis revealed a clear separation of patients and healthy controls using the aforementioned methodology.Some significantly changed metabolites were identified.Conclusions Use of the metabonomics method in patients with stomach cancer could effectively detect distinct changes in urinary metabolites and had the capacity to detect cancer; therefore,it may be a valuable tool in earlier diagnosis.Furthermore,the detection and identification of altered metabolites in the current study may help elucidate possible mechanisms involved in stomach cancer.
Keywords:stomach cancer  metabonomics  rapid resolution liquid chromatography-quadruple time of flight massspectrometry  biomarker
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