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Mitogen-activated protein kinase-dependent apoptosis in norcan-tharidin-treated A375-S2 cells is proceeded by the activation of protein kinase C |
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| Authors: | An Wei-Wei Wang Min-Wei Tashiro Shin-Ichi Onodera Satoshi Ikejima Takashi |
| Affiliation: | 1. China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China 2. Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China 3. Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University, Tokyo 19-8543, Japan |
| Abstract: | Background We have reported that norcantharidin (NCTD) induces human melanoma A375-S2 cell apoptosis and that the activation of caspase and the mitochondrial pathway are involved in the apoptotic process. This study aimed at investigating the roles of mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) in A375-S2 cell apoptosis induced by NCTD. |
| Keywords: | norcantharidin A375-S2 cells mitogen-activated protein kinase protein kinase C staurosporine |
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