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Effects of a plasmid expressing antisense tissue inhibitor of metalloproteinase-1 on liver fibrosis in rats |
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| Authors: | Jiang Wei Wang Ji-Yao Yang Chang-Qing Liu Wen-Bin Wang Yi-Qing He Bo-Ming |
| Institution: | Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, China |
| Abstract: | Background No efficient therapy for liver fibrosis has been available. This study was aimed to provide evidence that the introduction of a plasmid expressing antisense tissue inhibitor of metalloproteinase-1 (TIMP-1) into a rat model of immunologically induced liver fibrosis can result in the increased activity of interstitial collagenase, thus enhancing the degradation of collagen. |
| Keywords: | liver fibrosis antisense tissue-inhibitor of metalloproteinase-1 |
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