| Experimental study of acute lung injury induced by different tidal volume ventilation in rats |
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| 作者姓名： | Zhang XR DU YC Jiang HY Xu JY Xu YJ |
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| 作者单位： | [1]DepartmentofRespiratoryMedicine,TongjiHospital,TongjiMedicalCollage,HuazhongScienceandTechnologyUniversity,Wuhan430030,China [2]DepartmentofRespiratoryMedicine,FirstAffiliatedHospital,ShanxiMedicalUniversity,Taiyuan030001,China |
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| 基金项目： | ThisworkwassupportedbytheShanxiProvincialNaturalScienceFoundation(No 20041112) |
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| 摘 要： | Mechanical ventilation (MV) is a dual blade sward which if misused could lead to lung injury, called ventilator induced lung injury (VILI). Pathogenesis of VILI is very complex with various manifestations, which is the focus in MV field in recent years.^1 In our research, the rats were ventilated with different tidal volume,
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| 关 键 词： | 急性肺损伤 通风量 小鼠 动物模型 医学实验 |
Experimental study of acute lung injury induced by different tidal volume ventilation in rats |
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| Zhang XR,DU YC,Jiang HY,Xu JY,Xu YJ.Experimental study of acute lung injury induced by different tidal volume ventilation in rats[J].Chinese Medical Journal,2005,118(9):777-780. |
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| Authors: | Zhang Xin-ri DU Yong-cheng Jiang Hong-ying Xu Jian-ying Xu Yong-jian |
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| Institution: | 1. Department of Respiratory Medicine,Tongji Hospital,Tongji Medical Collage,Huazhong Science and Technology University,Wuhan 430030,China
2. Department of Respiratory Medicine,First Affiliated Hospital,Shanxi Medical University,Taiyuan 030001,China |
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| Abstract: | Mechanical ventilation (MV) is a dual blade sward which if misused could lead to lung injury, called ventilator induced lung injury (VILI). Pathogenesis of VILI is very complex with various manifestations, which is the focus in MV field in recent years. 1 In our research, the rats were ventilated with different tidal volume, then the pathological changes of the lungs were observed under macroscopy, light and electronic microscope, and various laboratory tests in blood and bronchoalveolar lavage fluid (BALF) were also carried out in order to probe further the pathologic characteristics and the pathogenesis of VILI. |
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| Keywords: | mechanical ventilation acute lung injury neutrophils myloperoxidase bronchoalveolar lavage fluid |
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