| Abstract: | In order to further understand the pattern of
activities of urethral tumor reappearance after
cystectomy for cancer of
with the condition and 10
the bladder, 900 patients
cases undergoing cystoure
threctomy were evaluated. Of 184 male patients
having total cystectomy, 18(10%) subsequently
developed urethral tumors, whereas of 570 patients
undergoing partial cystectomy only 6 (1%) developed
this kind of tumor. Of additional 10 patients on
whom en bloc cystourethrcctomy was performed
for concomitant presence of carcinoma in situ and
suspected urethral abnormality, 2 were carcinoma
in situ, 1 papdlary transitional cell carcinoma, and
3 marked epithelial atypia of the urethra. Histo-
pathologically, of the 24 bladder specimens, 15 were
G2, 9 G3, 14 T1-T2, and 10 T3-T4 according to their
grading and staging.
Of the 24 urethras removed, 8 had cancer at
the urethral stub, 5 had multiple lesions over the
entire urethra, and 11 with lesions at the anterior
urethra, of which most had no tumor cells micros
copically at the excised margin. These indicate that
tumor recurrence in the retained urethra following
cystectomy could be a reflection of tumor multicen-
tricity, particularly correlative to the histology and
locality of the primary vesical tumor. En bloc
cystourethrectomy is only justified when the extent
of the bladder lesion and its urethral involvement
are evident. |
