| CTX-M-14, CTX-M-24 and resistance in Escherichia coli and Klebsiella pneumoniae clinical isolates |
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| 作者单位： | Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China |
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| 基金项目： | This work was supported by a grant from the National Natural Science Foundation of China (No. 30070903). |
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| 摘 要： | Extended-spectrum β-lactamases (ESBLs) are the main cause of resistance to the third and forth-generation cephalosporins in Enterobacteriaceae which are mediated by plasmids and can hydrolyze oxyiminoaminothiazolyl cephalosporins and mono- bactams.1 Most of ESBLs are mutants of the classical TEM and SHV types, with one or more amino-acid substitution(s) in the active site. β-lactamase inhibitors, such as clavulanic acid, can inhibit their activities. Recently, The cefotaximases (CTX-…
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| 关 键 词： | extended-spectrum β -l actamases CTX-M-14 CTX-M-24 Escherichia coli Klebsiella pneumoniae |
CTX-M-14, CTX-M-24 and resistance in Escherichia coli and Klebsiella pneumoniae clinical isolates |
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| Authors: | XIONG Zi-zhong ZHU De-mei WANG Fu ZHANG Ying-yuan |
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| Abstract: | |
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| Keywords: | extended-spectrum β-lactamases CTX-M-14 CTX-M-24 Escherichia coli Klebsiella pneumoniae |
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