商丘地区妊娠期女性梅毒血清流行病学研究

目的探讨商丘地区妊娠期女性梅毒感染状况及妊娠梅毒对妊娠结局的影响。方法对2005年1月至2010年12月在我院进行梅毒血清检测的妊娠期女性行问卷调查并采集血液样本，用梅毒酶联免疫吸附法（TP—ELISA）筛检，用梅毒螺旋体明胶颗粒凝聚试验（TPPA）确证。对调查结果和检测结果进行流行病学分析，并追踪其妊娠结局。结果受调查的17544例妊娠女性中潜伏期梅毒145例，一期梅毒13例，二期梅毒6例，总计164例妊娠期梅毒感染，总感染率为0．94％。妊娠期感染梅毒女性中出现早产、流产、胎死宫内、婴儿先天性梅毒等不良妊娠结局高于妊娠期未感染梅毒女性。结论商丘地区妊娠期女性梅毒感染有逐年增加的趋势，妊娠女性的职业、文化水平、居住地、梅毒感染史、配偶职业和梅毒感染史以及妊娠女性经常接触人员梅毒感染史等是妊娠期女性梅毒感染的危险因素。妊娠期感染梅毒增加了不良妊娠结局的风险，应加强人群健康教育和孕前梅毒血清筛检管理，努力将梅毒对妊娠的危害降至最低限度。

Seroepidemiological study on pregnant syphilis in shangqiu area

Objective To investigate women in gestation period who were infected with pregnant syphilis and how it influenced pregnant outcome. Methods From January 2005 to December 2010, a seroepidemiological survey on pregnant women who were infected pregnant syphilis was conducted in our hospital and some blood samples were collected. Used TP - ELISA to filtrate this, then used TPPA to confirm whether it was practical. Some information and serological test results were analysed and we would track some pregnant women under investigation. Results The number of surveyed pregnant women was 17 544, the number of latent syphilis was 145, 13 cases of Ⅰstage syphilis, 6 cases of Ⅱ stage syphilis, syphilis infection altogether 164. The total infection rate was 0.94%. In all the gestational women who were infected with syphilis, some other things appeared, such as premature infant, abortion, stillbirth, baby with congential syphilis and other in pregnant outcome. Conclusions The pregnant syphilis infection is increasing trend year by year in this area. These women＇ s cultural level,residence, professional, age and their husbands＇ cultural level, professional, the history of syphilis infection and they often contact somepeople who have been infected with syphilis are dangerous factors that are related to pregnant syphilis. So we should strengthen the heath education and consummate couple syphilis serological screening before pregnancy and management, and make the effect of syphilis on pregnancy drop to the minimum.