白细胞介素-6、白细胞介素-8及肿瘤坏死因子-α与脑出血患者出血量及预后的关系

目的研究脑出血患者血清白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF—α）含量的变化及其与出血量、预后的关系。方法分别测定60例脑出血患者和20例健康体检者（对照组）血清IL-6、IL-8及TNF-α含量，观察比较脑出血患者在不同出血量（小、中、大量）时的含量变化，同时对出院者进行神经功能缺损评分（NDS）评定，观察IL-6、IL-8及TNF—α含量水平对脑出血预后生活质量的影响。结果脑出血组血清IL-6、IL-8及TNF—α含量显著高于对照组，差异有统计学意义（P〈0．05）；脑出血患者大量、中量组的IL-6、IL-8及TNF—α含量显著高于小量组（P〈0．05）；大量组的IL-6、IL-8及TNF—α含量显著高于中量组（P〈0．05）。脑出血患者血清中IL-6、IL-8及TNF-α含量越高，NDS越高。结论血清中IL-6、IL-8及TNF-α含量的测定可能反映脑出血患者的出血量，还可以预测患者的预后。

Relationship among the serum levels of IL - 6, IL - 8, TNF - α and hemorrhage volume and prognosis after cerebral hemorrhage

Objective To investigate the correlation of serum IL ~ 6, IL - 8 and TNF - ct con- centrations with hemorrhage volume and prognosis in cerebral hereon＇ha. Methods The contents of IL- 6, IL - 8 and TNF - α in 60 patients with cerebral hemorrhage and 20 controls were measured. The chan- ges in IL - 6, IL - 8 and TNF - α were compared among the patients of different hemorrhage volume （small, medium, large volume）. The correlation analysis between IL- 6, IL- 8 and TNF-α was also made. The neurological deficit scores（NDS） at the time of discharge was compared in patients with different hemorrhage volume. Results The levels of IL - 6, IL - 8 and TNF - α in cerebral hemorrhage group were significantly higher than that in control group （ P 〈 0.05 ） . The levels of IL - 6, TL - 8 and TNF-α in patients with large and medium volume were significantly higher than those in patients with small volume （ P 〈 0. 05 ）. The levels of both IL - 6, IL - 8 and TNF - α in patients with large volume were significantly higher than those in patients with medium volume （ P 〈 0.05）. The higher of the serum IL - 6, IL - 8 and TNF -α level, the higher of the NDS（ P 〈0.05）. Conclusions IL - 6, IL - 8 and TNF - α in blood during cerebral hemorrhage are useful markers of hemorrhage volume, and they may serve as prognostic markers in the future.