血清肿瘤标记物联合动态检测在乳腺癌早期诊断和监控治疗中的价值

目的探讨血清肿瘤标志物肿瘤抗原CA15—3、细胞角蛋白19片段抗原CYFRA21-1、骨桥蛋白OPN和肿瘤抗原CA125联合动态检测在乳腺癌早期诊断和监控治疗中的价值。方法采用电化学发光法检测126例乳腺癌组患者血清CA15—3、CYFRA21—1和CA125，酶联免疫法检测OPN水平，并与良性对照组（50例）比较，分析与乳腺癌临床分期和复发转移的关系。结果乳腺癌组患者血清CA15-3、CYFRA21．1、OPN和CA125水平明显高于乳腺良性对照组（P〈0．01）；乳腺癌高分期（Ⅲ、Ⅳ期）组明显高于低分期（Ⅰ、Ⅱ期）组（P〈0．05）；复发组与无复发组比较差异有统计学意义（P〈0．05）；四项联合检测诊断乳腺癌的敏感性为95．2％，与备单项检测敏感性比较差异有统计学意义（P〈0．05）。结论血清学CA15—3、CYFRA21—1、OPN和CA125水平与乳腺癌临床分期、复发转移相关，联合动态检测是乳腺癌早期诊断和监控复发治疗的较好指标，有利于临床早期发现、早期干预。

Value of serum tumor markers combined with motion detection in early diagnosis and monitor treatment of breast cancer

Objective To investigate the value of combined dynamic assay of serum tumor mark-er CA15-3, CYFRA21-1, OPN （osteopontin） and CA125 on early diagnosis and treatment of breast cancer. Methods Serum levels of CA15-3, CYFRA21-1 and CA125 in 126 breast cancer cases were detected by electrochemiluminescenee immunoassay, level of OPN was detected by enzyme linked immu-noassay. Also serum level of the indexes were detected in 50 healthy people, then the data were analyzed and the difference and relationship in clinic stage, recurrence and metastasis of breast cancer were found. Results The serum levels of CAIS-3, CYFRA21-1, OPN or CA125 in patients with breast cancer were significantly higher than those in normal contrast（P 〈0. 01 ）. Serum levels of indexes in stage Ⅲ and Ⅳ patients were significantly higher than those in stage Ⅰ and Ⅱ patients （P 〈 0. 05 ）. Static significance was detected in levels of cancer recurrence people and non-recurrence people （P 〈 0. 05）. Positive de-tection rate of combined assay of the 4 indexes was 95.2%. And there was statistical significance be-tween positive detection rates of combines assay group and single group. Conclusions Serum levels of CA15-3,CYFRA21-1,OPN and CA125 were closely related with clinic stage, recurrence and metastasis of breast cancer. Combined dynamic assay of the 4 indexes are better value for early diagnosis and treat-ment of breast cancer, and will contribute to the early diagnosis and treatment of breast cancer.