胸腔灌注重组人p53腺病毒联合顺铂等治疗肺癌胸腔积液 |
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引用本文: | 王文玉,;樊红琨,;周云,;刘明月,;李晓燕,;崔勇霞. 胸腔灌注重组人p53腺病毒联合顺铂等治疗肺癌胸腔积液[J]. 中原医刊, 2009, 0(20): 8-9 |
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作者姓名: | 王文玉, 樊红琨, 周云, 刘明月, 李晓燕, 崔勇霞 |
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作者单位: | [1]河南省人民医院肿瘤科,郑州450003; [2]郑州大学基础医学院生理教研室,郑州450003; |
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摘 要: | 目的评价胸腔置管灌注重组人p53腺病毒(rAd/p53)联合顺铂等治疗肺癌恶性胸腔积液的疗效和安全性。方法38例肺癌恶性胸腔积液患者,胸腔置管灌注1×10^12VP,每周1次,48~72h内则序贯应用顺铂注射液80mg或5-氟尿嘧啶1.5g或表柔比星60mg,每周1种/1次。结果38例患者中完全缓解16例(42.1%),部分缓解18例(47.4%),无效4例(10.5%),总有效率89.5%。主要不良反应为寒战发热76.3%(29/38)、胸痛55.3%(21/38)、恶心呕吐68.4%(26/38),均可耐受。生活质量karnofsky评分,提高20分以上者23例(60.5%),提高10-20分7例(18.4%)。结论rAd/p53注射液联合顺铂等治疗肺癌恶性胸腔积液疗效较好,无明显不良反应,对患者的生活质量有较好改善。
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关 键 词: | 重组人p53腺病毒注射液 肺癌 恶性胸腔积液 |
Perfusion treatment with .recombinant adenoviral - mediated p53 gene transfer and cisplatin through an intrapleural catheter for lung cancer with malignant pleural effusion |
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Affiliation: | WANG Wen-yu, FAN Hong-kun,ZHOU Yun, LIU Ming-yue, LI Xiao-yan, CUI Yong-xia(Department of Medical Oncology, Henan Provincial People's Hospital, Zhengzhou 450003 ,China) |
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Abstract: | Objective To evaluate the therapeutic effects and adverse reactions of recombinant adenoviral - mediated 1353 gene transfer( rAd/p53 ) combined with cisplatin and so all in the treatment of lung cancer with malignant pleural effusion. Methods Thirty - eight lung cancer patients with malignant pleural effusion, were infused intrapleurally with rAd/p53 at a dose of 1 ×10^12VP every time through an intrapleural catheter, one time a week, then cisplatin 80 mg or 5 - fluorouracil 1.5 g or epidoxorubcin 60 mg by sequence in 48 - 72 hours, one kind and one time a week. Results Among the 38 cases, 16 completely recovered(42.1% ), 18 partial recovered(47.4% ), and 4 coases no changed( 10.5% ). The overall effective rate was 89.5%. The major adverse effects were fever in 29 cases (76.3%)and chest pain in 21 cases (55.3%) and nausea or vomit in 26 cases(68.4% ). Life quality for the patients was improved after treatment. The Karnofsky score rose by over 20% in 23 cases(60.5% ) and 10% - 20% in 7 cases( 18.4% ). Conclusions rAd/p53 transfer combined with cisplatin and so all is effective and safe for the control of lung cancer with malignant pleural effusion. The life quality for the patients was improved. |
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Keywords: | Recombinant adenoviral - mediated p53 gene transfer Lung cancer Malignant pleural effusion |
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