单纯性肥胖中年男性合并心血管危险性因素的7年随访观察

目的研究单纯性肥胖中年男性超重／肥胖的临床特点及与合并心血管危险性因素的关系。方法本研究以2000年至2001年体重指数（BMI）≥25kg／m^2的单纯性肥胖中年男性人群268例为研究对象，检测BMI、腰臀比（WHR）、血压、血糖和胰岛素、血脂及胰岛素抵抗指数（HOMA—IR），并测定血管内皮舒张功能（EDD）等，进行7年随访调查，对其合并心血管病并发症及危险因素等进行相关研究。结果按BMI分层，不同BMI组心血管危险因素包括吸烟、高血压、高血糖、血脂紊乱、EDD等患病比例比较差异有统计学意义（P〈0．05），且随着BMI的增加，上述心血管危险因素检出率及聚集率明显升高，EDD则进行性下降（P〈0．05）。Logistic回归分析显示，WHR、空腹血糖、甘油三酯、HOMA—IR和EDD与中年男性超重／肥胖呈密切相关，是发生心血管疾病的独立危险因素。结论石家庄单纯性肥胖中年男性存在较严重的超重／肥胖状况及多种心血管危险因素聚集，因此，防治肥胖对预防心血管相关疾病发生具有重要临床的临床意义。

Simple obesity in middle - aged male combined cardiovascular risk factors of the 7 - year follow - up observation

Objective To study the relationship of the clinical characteristics of the simple obesity adults and cardiovascular risk factors in middle - aged male. Methods In this study, from 2000 to 2001 on the body mass index （BMI） ≥25 kg/m^2 simple obesity of middle -aged male for the 268 cases studied, the BMI, waist -hip ratio （WHR）, blood pressure, blood glucose and insulin, blood lipid and HOMA - IR, and endothelium dependent - dilatation （EDD） were detected, for 7 - year follow - up investigation, the prevalence of the cardiovascular complications and risk factors were researched. Results Stratified by BMI, the cardiovascular risk factors including smoking, high blood glucose, high blood glucose,blood lipid disorders, EDD had significant differences in BMI different groups （ P 〈 0.05 ）, and with the increase in BMI, the accumulation rate of the cardiovascular risk factors were increased, while EDD was progressive declined （ P 〈 0.05 ）. Logistic regression analysis showed that, WHR, FPG, TG, HOMA- IR, EDD had closely relationship with overweight/obesity, and might be the independent risk factorsin the occurrence of cardiovascular disease. Conclusions The middle - aged male patients of Shijiazhuang may have more serious overweight/obesity situation and gather a variety of cardiovascular risk factors, prevention and treatment of obesity may play an important role to reduce the cardiovascular - related disease.