| 神经生长因子对新生大鼠缺氧缺血性脑病的保护作用 |
| |
| 引用本文： | 吴秀孝,张善锋,赵荷剑,毛红丽,王明臣.神经生长因子对新生大鼠缺氧缺血性脑病的保护作用[J].中原医刊,2006,33(17):10-12. |
| |
| 作者姓名： | 吴秀孝 张善锋 赵荷剑 毛红丽 王明臣 |
| |
| 作者单位： | 河南省固始县人民医院儿科，郑州大学基础医学院，郑州大学基础医学院，郑州大学第一附属医院检验科，郑州大学基础医学院 固始465231 |
| |
| 摘 要： | 目的探讨神经生长因子(NGF)对新生大鼠缺氧缺血性脑病(H IE)的保护作用。方法建立H IE新生大鼠模型,给予腹腔注射NGF后,通过组织学观察、分光光度法及原位末端标记法对比观察NGF对H IE模型鼠脑组织结构、超氧化物歧化酶(SOD)活性、丙二醛(MDA)及一氧化氮(NO)的含量和凋亡细胞数的影响。结果NGF组MDA、NO含量及凋亡细胞数明显低于模型组的测定值;SOD活性显著高于模型组的测定值。结论NGF能提高抗氧化酶活性,抑制氧自由基生成,阻断NO的异常代谢,降低细胞凋亡数,对H IE具有保护作用。
|
| 关 键 词： | 神经生长因子 HIE 抗氧化 凋亡 |
| 收稿时间： | 2006-06-16 |
| 修稿时间： | 2006年6月16日 |
Protective effect of nerve growth factor on hypoxic - ischemic encephalopathy in neonatal rats |
| |
| WU Xiuxiao,ZHANG Shanfeng,ZHAO Hejian,MAO Hongli, WANG Mingchen.Protective effect of nerve growth factor on hypoxic - ischemic encephalopathy in neonatal rats[J].Central Plains Medical Journal,2006,33(17):10-12. |
| |
| Authors: | WU Xiuxiao ZHANG Shanfeng ZHAO Hejian MAO Hongli WANG Mingchen |
| |
| Abstract: | Objective To investigate the prevention effect of nerve growth factor(NGF) on hypoxic-ischemic encephalopathy in neonatal rats.Methods The HIE models were made with 7-day-old SD rats,NGF was injected into the HIE models.The contents of SOD,MDA and NO in the left and right brains and the number of cell apoptosis were measured.Results The contents of MDA,NO and the number of cell apoptosis were much lower in NGF group than those in control group.The values of activity of SOD were much higher in NGF group than that in control group.Conclusion NGF has effects on HIE rats by blocking abnormal metabolism of NO,repressing production of oxygen free radical enhancing the activity of antioxidant enzyme,decreasing the number of cell apoptosis.NGF can prevent hypoxic-ischemic encephalopathy. |
| |
| Keywords: | Nerve growth factors Hypoxic-ischemic encephalopathy Apoptosis |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
