|
|||||
|
|
| 四联疗法治疗幽门螺杆菌阳性十二指肠球部溃疡疗效观察 | |
| 引用本文： | 何明顺,漆红,李志.四联疗法治疗幽门螺杆菌阳性十二指肠球部溃疡疗效观察[J].中国全科医学,2010,13(11):1163-1164. |
| 作者姓名： | 何明顺 漆红 李志 |
| 作者单位： | 1. 南充市,南部县人民医院消化内科,四川省,637300 2. 遂宁市中心医院消化内科 3. 泸州医学院附属第二医院消化内科,四川省泸州市,646000 |
| 摘 要： | 目的 观察含雷贝拉唑的四联4日疗法根除幽门螺杆菌(Hp)的效果及其治疗Hp阳性十二指肠球部溃疡的疗效.方法 选择120例Hp阳性十二指肠球部溃疡患者,将其随机分为治疗组和对照组,各60例.治疗组口服雷贝拉唑10 mg/次,雷尼替丁枸橼酸铋(RBC)350 mg/次,阿莫西林1 000 mg/次,呋喃唑酮100 mg/次,均2次/d,共4 d.对照组口服奥美拉唑20 mg/次,阿莫西林1 000 mg/次,克拉霉素500 mg/次,均2次/d,共7 d.抗Hp治疗后继续服用雷贝拉唑10 mg/次或奥美拉唑20 mg/次,1次/d,疗程2周.观察治疗后4～6周时的Hp根除率、溃疡愈合率及随访半年、1年时的溃疡复发率和Hp再感染率.结果 治疗后4～6周,治疗组和对照组溃疡愈合率分别为98.2%和93.1%,差异无统计学意义(P＞0.05);Hp根除率分别为96.4%和77.6%,差异有统计学意义(P＜0.01).治疗组和对照组随访半年溃疡复发率分别为3.8%和15.7%,随访1年分别为5.9%和20.0%,差异均有统计学意义(P＜0.05);随访半年Hp再感染率分别为7.5%和21.6%,随访1年分别为11.8%和28.0%,差异均有统计学意义(P＜0.05).结论 含雷贝拉唑和RBC的四联4日疗法是一种短程、高效、安全的根除Hp和促进溃疡愈合的方法. |
| 关 键 词： | 雷贝拉唑 雷尼替丁枸橼酸铋 螺杆菌 幽门 十二指肠溃疡 |
Curative Effect of Quadruple Chemotherapy in Treating Helicobacter Pylori-positive Duodenal Bulbar Ulcer |
|
| HE Ming-shun,QI Hong,LI Zhi.Curative Effect of Quadruple Chemotherapy in Treating Helicobacter Pylori-positive Duodenal Bulbar Ulcer[J].Chinese General Practice,2010,13(11):1163-1164. | |
| Authors: | HE Ming-shun QI Hong LI Zhi |
| Institution: | HE+Ming-shun,QI+Hong,LI+Zhi.Department+of+Gastroenterology,People%e2%80%b2s+Hospital+of+Nanbu+County+of+Nanchong,Nanchong+637300,China |
| Abstract: | Objective To observe the effects of the quadruple chemotherapy including rabeprazole on Helicobacter pylori(Hp) and on Hp-positive duodenal bulbar ulcer.Methods One hundred and twenty patients with Hp-positive duodenal bulbar ulcer were randomized into groups therapy and control,60 in each.Therapy group received oral rabeprazole(10 mg/times),ranitidine bismuth citrate(RBC,350 mg/times),amoxicillin(1 000 mg/times),furazolidone(100 mg/times),twice/d,4 d altogether.Control group received oral omeprazole(20 mg/... |
| Keywords: | Rabeprazole Ranitidine bismuth citrate Helicobacter pylori Duodenal ulcer |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |