| 瑞舒伐他汀钙联合缬沙坦治疗早期糖尿病肾病疗效观察 |
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| 引用本文： | 王晓东,李红涛,包春艳,马波,兰丽娟,吴书元,杨涛.瑞舒伐他汀钙联合缬沙坦治疗早期糖尿病肾病疗效观察[J].中国全科医学,2011,14(33). |
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| 作者姓名： | 王晓东 李红涛 包春艳 马波 兰丽娟 吴书元 杨涛 |
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| 作者单位： | 武警天津市总队医院,天津市,300162 |
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| 摘 要： | 目的探讨瑞舒伐他汀钙联合缬沙坦对早期糖尿病肾病(DN)的保护作用。方法将97例早期DN患者随机分为对照组、缬沙坦单药治疗组(单药治疗组)、瑞舒伐他汀钙与缬沙坦联合治疗组(联合治疗组)。3组患者均行常规降糖治疗,单药治疗组在常规降糖治疗基础上加用缬沙坦80 mg/d,联合治疗组在常规降糖治疗基础上加用缬沙坦80 mg/d和瑞舒伐他汀钙片10 mg/d。疗程均为12周。检测并比较治疗前后3组患者血糖空腹血糖(FBG)、餐后血糖(PBG)]、血脂总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、糖化血红蛋白(HbA1c)、血肌酐(SCr)及24 h尿微量清蛋白排泄率(UAER)等指标的变化。结果治疗后,联合治疗组患者血脂TC、TG、LDL-C]、血糖(FBG、PBG)、HbA1c、UAER均较治疗前显著降低,差异有统计学意义(P<0.05);且治疗后联合治疗组与单药治疗组比较,血脂、UAER也显著降低,差异有统计学意义(P<0.05);3组患者SCr水平无论在治疗前还是治疗后,差异均无统计学意义(P>0.05)。结论瑞舒伐他汀钙与缬沙坦联合治疗早期DN,...
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| 关 键 词： | 糖尿病肾病 瑞舒伐他汀钙 缬沙坦 治疗结果 |
Evaluation of the Therapeutic Effects of Rosuvastatin Combined with Valsartan in Treating Early Diabetic Nephropathy |
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| WANG Xiao-dong,LI Hong-tao,BAO Chun-yan,et al..Evaluation of the Therapeutic Effects of Rosuvastatin Combined with Valsartan in Treating Early Diabetic Nephropathy[J].Chinese General Practice,2011,14(33). |
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| Authors: | WANG Xiao-dong LI Hong-tao BAO Chun-yan |
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| Institution: | WANG Xiao-dong,LI Hong-tao,BAO Chun-yan,et al.Hospital of Tianjin Armed Police Forces,Tianjin 300162,China |
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| Abstract: | Objective To observe the clinical efficacy of Rosuvastatin combined with Valsartan in early diabetic nephropathy.Methods A total of 97 patients of early diabetic nephropathy were randomly divided into 3 groups(the Valsartan therapy group,the Rosuvastatin and Valsartan combined group and the control group).All the three groups received routine treatment,the Valsartan therapy group received additional oral valsartan(80 mg/d),and the combined group received additional oral Rosuvastatin(10 mg/d) combined with v... |
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| Keywords: | Diabetic nephropathies Rosuvastatin Valsartan Treatment outcome |
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