| 血液灌流对尿毒症患者同型半胱氨酸和氧化应激状态的影响 |
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| 引用本文： | 许传文,徐艳梅.血液灌流对尿毒症患者同型半胱氨酸和氧化应激状态的影响[J].中国全科医学,2011,14(30). |
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| 作者姓名： | 许传文 徐艳梅 |
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| 作者单位： | 430030湖北省武汉市普爱医院肾内科 |
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| 摘 要： | 目的探讨血液透析(HD)联合血液灌流(HP)对尿毒症透析患者同型半胱氨酸(Hcy)及氧化应激状态的影响。方法选择尿毒症患者100例,随机分为两组:HD+HP组和HD组,分别于治疗前、后采血检测血浆中脂质过氧化物丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)及Hcy的水平。结果两组患者治疗后MDA、SOD、GSH-Px、Hcy水平比较,差异均有统计学意义(P<0.01);HP+HD组患者治疗前后MDA、SOD、GSH-Px、Hcy水平比较,差异均有统计学意义(P<0.05)。结论 HD联合HP治疗尿毒症可使血清Hcy水平下降,改善患者氧化应激的状态。
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| 关 键 词： | 尿毒症 血液灌流 肾透析 半胱氨酸 氧化应激 |
Impact of Hemoperfusion on Homocysteine and Oxidative Stress Status of Uremic Patients |
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| XU Chuan-wen,XU Yan-mei.Impact of Hemoperfusion on Homocysteine and Oxidative Stress Status of Uremic Patients[J].Chinese General Practice,2011,14(30). |
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| Authors: | XU Chuan-wen XU Yan-mei |
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| Institution: | XU Chuan-wen,XU Yan-mei.Department of Nephrology,Puai Hosipital,Wuhan 430030,China |
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| Abstract: | Objective To investigate the impact of hemodialysis(HD) combined with hemoperfusion(HP) on homocysteine and oxidative stress status of uremic patients.Methods A total of 100 patients with uremia were randomly divided into two groups:the(HD + HP)group and the HD group.Plasma levels of malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) and homocysteine(Hcy) were determined before and after treatment in both groups.Results MDA,SOD,GSH-Px,Hcy levels were significantly different betwee... |
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| Keywords: | Uremia Hemoperfusion Renaldialysis Cysteine Oxidative stress |
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