| 高压氧治疗新生儿缺氧缺血性脑病的疗效及其对血清白介素-6和一氧化氮的影响 |
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| 引用本文： | 王慧,王立金.高压氧治疗新生儿缺氧缺血性脑病的疗效及其对血清白介素-6和一氧化氮的影响[J].中国全科医学,2008,11(24):2213-2214. |
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| 作者姓名： | 王慧 王立金 |
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| 作者单位： | 1. 新华医疗集团新华医院儿科,安徽省淮南市,232052
2. 安徽理工大学医学院病理生理教研室,安徽省淮南市,232052 |
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| 摘 要： | 目的探讨高压氧(HBO)治疗新生儿缺氧缺血性脑病(HIE)的疗效及其对血清白介素-6(IL-6)和一氧化氮(NO)的影响。方法将60例HIE患儿随机分为常规治疗组和HBO治疗组,比较两组的疗效;另选择10例正常新生儿为对照组,对3组新生儿的血清IL-6和NO水平进行测定并比较。结果HBO治疗组和常规治疗组患儿的临床疗效间差异有统计学意义(P<0.05);治疗前常规治疗组、HBO治疗组的IL-6和NO水平与对照组间差异均有统计学意义(P<0.01);HBO治疗组治疗前后IL-6的差值、NO的差值与常规治疗组治疗前后的差值比较,差异均有统计学意义(P<0.05)。结论HBO治疗HIE有较好疗效;HBO治疗HIE可能是通过降低IL-6和NO水平而减轻脑细胞损害的。
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| 关 键 词： | 高压氧 缺氧缺血 脑 白介素-6 一氧化氮 婴儿 新生 |
Curative Effects of Hyperbaric Oxygen Therapy on Hypoxic-ischemic Encephalopathy and Its Influence on Serum Interleukin-6 and Nitric Oxide |
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| WANG Hui,WANG Li-jin.Curative Effects of Hyperbaric Oxygen Therapy on Hypoxic-ischemic Encephalopathy and Its Influence on Serum Interleukin-6 and Nitric Oxide[J].Chinese General Practice,2008,11(24):2213-2214. |
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| Authors: | WANG Hui WANG Li-jin |
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| Abstract: | Objective To study the effect of hyperbaric oxygen therapy(HBOT) on serum IL-6 and Nitric Oxide(NO) in newborns with hypoxic-ischemic encephalopathy(HIE).Methods Sixty HIE patients were randomly divided into HBO group and routine-treatment,and10 normal newborns served as control.Serum IL-6 and NO levels were determined before and after HBOT.Results There was significant difference in curative effect between HBO and routine-treatment groups(P<0.05);A significant decrease in serum IL-6 and NO was demonstrated after HBOT(P<0.01).Conclusion HBO may decrease the brain cell injury by lowering IL-6 and NO levels.It is of relatively greater effect in treating HBO. |
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| Keywords: | Hyperbaric oxygenation Hypoxia-ischemia brain Interleukin-6 Nitric oxide Infant newborn |
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