炎症性肠病患者生存质量问卷调查研究

目的应用炎症性肠病生存质量问卷(IBDQ)评价炎症性肠病(IBD)患者的生存质量。方法选择172例门诊及住院IBD患者进入本研究,IBD病情评估:溃疡性结肠炎(UC)参考True-Love标准分为轻型、中型、重型。克罗恩病(CD)依据Harvey和Bradshaw标准分组:积分<4分为缓解期,4～8分为中度活动期,≥9分为重度活动期。调查以面谈方式进行。营养风险评估采用NRS2002方法。结果 172例患者中UC 102例,CD 70例;男95例,女77例。患者IBDQ总分及其4个维度评分与病情严重程度呈负相关(P<0.001)。CD组缓解期和活动期的IB-DQ总分间差异有统计学意义(P<0.001),但中度活动组和重度活动组的IBDQ总分间差异无统计学意义(P=0.366)。患者疾病诊断(UC或CD)、年龄、性别、医疗费用以及营养风险等因素与IBDQ评分无显著相关。结论IBDQ与IBD患者病情严重程度呈负相关,可有效评价患者的生存质量。

Health-Related Quality of Life in Patients with Inflammatory Bowel Disease

Objective To assess the health-related quality of life in patients with inflammatory bowel disease(IBD) by inflammatory bowel disease questionaire(IBDQ).Methods Totally 172 patients from the in-hospital and clinical services in Peking Union Medical College Hospital were enrolled in this study.The severity of IBD was evaluated by Truelove criteria for ulcerative colitis(UC) and Harvey-Bradshaw criteria for Crohn′s disease(CD).Patients were divided into three groups:mild group(or remission group),moderate group,and severe group.IBDQ was completed by interview.Nutritional status was evaluated by nutritional risk screening(NRS2002).Results Totally 172 patients(UC,n=102;CD,n=70;male,n=95,female,n=77) completed the IBDQ.The total score of IBDQ as well as all 4 domains negatively correlated with disease activity(P<0.001).The IBDQ was able to discriminate between active and inactive CD(P<0.001),but it could not discriminate between moderate active and severe active CD(P=0.366).There were no significant correlations between the total score of IBDQ and patient′s diagnosis(UC or CD),age,sex,medical insurance,or nutritional risk(P>0.05).Conclusion IBDQ is negatively correlated with the severity of IBD and therefore can be used to assess the health-related quality of life of patients with IBD.