代谢综合征高危人群心血管危险因素综合干预效果

目的评价综合干预对代谢综合征(MS)高危人群心血管危险因素的影响。方法对经常住院的100例MS高危人群(干预组)进行综合干预,随访2年。另选一般临床资料与干预组相匹配的60例由于工作繁忙无时间进行系统干预的MS高危人群作为对照组。观察两组患者干预前后的腰围、体质指数(BMI)、收缩压(SBP)和舒张压(DBP)、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)和C-反应蛋白(CRP)的变化。结果干预前两组患者腰围、BMI、SBP、DBP、HDL-C、LDL-C、TG、FBG、FINS、HOMA-IR、CRP水平间差别无统计学意义(P>0.05)。干预后两组患者除LDL-C和TG外,其他各项检测指标间差别均有统计学意义(P<0.05)。结论综合干预可改善MS高危人群的肥胖,降低血压和血糖,增加HDL-C水平,降低胰岛素抵抗和CRP水平。

Comprehensive Intervention of Cardiovascular Risk Factors in Metabolic Syndrome High-Risk Groups

Objective To evaluate the effects of comprehensive intervention of cardiovascular risk factors in metabolic syndrome(MS) high-risk groups.Methods Comprehensive intervention was carried out on 100 cases of repeatedly hospitalized MS high-risk population(intervention group),and follow-up was done for 2 years.Another 60 cases whose general data were commensurate with intervention group,who didn't receive intervention due to their busy work,were chosen from MS high-risk popuplation as control group.We observed the changes of waist circumference,body mass index(BMI),systolic blood pressure(SBP) and diastolic blood pressure(DBP),high-density lipoprotein cholesterol(HDL-C),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),fasting plasma glucose(FPG),fasting insulin(FINS),insulin resistance index(HOMA-IR) and C-reactive protein(CRP) before and following intervention.Results There was no significant difference in waist circumference,BMI and levels of SBP,DBP,HDL-C,LDL-C,TG,FBG,FINS,HOMA-IR,CRP between two groups before intervention(P<0.05);significant difference was found in waist circumference,BMI and levels of SBP,DBP,HDL-C,FBG,FINS,HOMA-IR,CRP between two groups after intervention(P<0.05).Conclusion Comprehensive intervention can improve obesity,increase level of HDL-C and reduce blood pressure,blood sugar and levels of insulin resistance and CRP in MS high-risk population.