| 血清NGAL和Cystatin C对糖尿病肾病早期诊断的意义研究 |
| |
| 引用本文： | 童俊容,何凤,罗正茂,张虹,王妍春,黄远航,王寅,张建林.血清NGAL和Cystatin C对糖尿病肾病早期诊断的意义研究[J].中国全科医学,2010,13(8):810-812. |
| |
| 作者姓名： | 童俊容 何凤 罗正茂 张虹 王妍春 黄远航 王寅 张建林 |
| |
| 作者单位： | 广州军区广州总医院肾内科,广东省广州市,510010 |
| |
| 摘 要： | 目的 探讨糖尿病肾病(DN)患者血清NGAL、Cystatin C的改变及其对DN早期诊断的临床意义.方法 选择2型糖尿病(T2DM)患者55例,根据尿清蛋白排泄率(UAER)分为3组,正常清蛋白尿(NA)组15例、微量清蛋白尿(MA)组17例、临床肾病(CN)组23例;同期选取非肾病患者15例作为对照组.应用ELISA法检测患者血清NGAL(sNGAL)水平,应用免疫速率散射比浊法检测Cystatin C水平,分析血清NGAL及Cystatin C水平与肾小球滤过率(GFR)之间的相关关系,应用受试者操作特征(ROC)曲线评价二者诊断DN的敏感度.结果 (1)MA组、CN组患者血清NGAL和Cystatin C水平均较对照组升高,差异有统计学意义(P＜0.05),其中CN组患者血清NGAL和Cystatin C水平最高分别为(845.8±68.8)ng/ml 和(3.58±1.21)mg/L].(2)Pearson相关分析:糖尿病患者血清NGAL和Cystatin C水平与GFR均呈负相关(r值分别为-0.871和-0.792,P＜0.01),且血清NGAL与GFR的相关性更密切.(3)两组患者血清NGAL和Cystatin C ROC曲线下的面积分别为0.839和0.720.结论 糖尿病患者血清NGAL与GFR有较好的相关性,NGAL是诊断早期DN敏感而准确的指标,有望用于临床监测.
|
| 关 键 词： | 糖尿病肾病 早期诊断 |
Value of Serum NGAL and Cystatin C in Diagnosing Early Phase of Diabetic Nephropathy |
| |
| TONGJun-rong,HEFeng,LUOZheng-mao,etal.Value of Serum NGAL and Cystatin C in Diagnosing Early Phase of Diabetic Nephropathy[J].Chinese General Practice,2010,13(8):810-812. |
| |
| Authors: | TONGJun-rong HEFeng LUOZheng-mao etal |
| |
| Institution: | TONG+Jun-rong,HE+Feng,LUO+Zheng-mao,et+al.Department+of+Nephrology,Guangzhou+Army+General+Hospital,Guangzhou+510010,China |
| |
| Abstract: | Objective To explore the clinical changes and diagnostic significance of serum neutrophil gelatinase-associated lipocalin(NGAL) and Cystatin C in patients with diabetic nephropathy(DN).Methods Fifty T2DM patients were divided,according to urinary albumin excretion rate (UAER),into groups NA (normal albuminuria,n=15),MA (microalbuminuria,n=17),CN (clinical nephropathy,n=23),and another 15 patients without nephropathy were chosen as control group.NGAL level was detected by ELISA,Cystatin C level by particle-e... |
| |
| Keywords: | NGAL Cystatin C NGAL Cystatin C Diabetic nephropathy Early diagnosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
