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手足口病危险因素研究
引用本文:张伟伟,李 亮,孟繁岳,李靖欣,嵇 红,董玉颖,潘红星,储 凯,许 可,朱凤才.手足口病危险因素研究[J].南京医科大学学报,2012(4):495-499.
作者姓名:张伟伟  李 亮  孟繁岳  李靖欣  嵇 红  董玉颖  潘红星  储 凯  许 可  朱凤才
作者单位:东南大学公共卫生学院流行病与卫生统计学系,江苏 南京 210009;江苏省疾病预防控制中心急性传染病防治所,江苏 南京 210009;江苏省疾病预防控制中心急性传染病防治所,江苏 南京 210009;江苏省疾病预防控制中心急性传染病防治所,江苏 南京 210009;江苏省疾病预防控制中心急性传染病防治所,江苏 南京 210009;东南大学公共卫生学院流行病与卫生统计学系,江苏 南京 210009;江苏省疾病预防控制中心急性传染病防治所,江苏 南京 210009;江苏省疾病预防控制中心急性传染病防治所,江苏 南京 210009;江苏省疾病预防控制中心急性传染病防治所,江苏 南京 210009;江苏省疾病预防控制中心急性传染病防治所,江苏 南京 210009
摘    要:目的:探索江苏省北部部分地区手足口病(hand-foot-mouth disease,HFMD)发病的危险因素?方法:采用问卷调查的方式,在江苏省盐城市和淮安市6个县(区)回顾性调查儿童在过去3年间的HFMD患病史,采用单因素分析和多因素Logistic回归分析,分析影响HFMD的主要危险因素?结果:1 239名调查对象中,HFMD患者为170例,此队列人群发病密度为50.36/1 000人年,门诊病例和住院病例分别为153?17例?单因素分析发现5个暴露因素和HFMD发生有关;多因素分析显示HFMD有3个危险因素和2个保护因素,分别为:性别为男性(OR=1.60,95%CI:1.12~2.27),居住在城镇(OR=1.71,95%CI:1.15~2.53),患儿经常发生上呼吸道感染?腹泻等(OR=1.96,95%CI:1.20~3.21),纯母乳喂养时间为3~6个月(OR=0.39,95%CI:0.17~0.84),饭前便后洗手(OR=0.54,95%CI:0.36~0.81)?结论:城镇人口密度大,接触传播是HFMD传播方式之一,因此减少儿童与患者接触对于控制HFMD传播起到重要作用?此外,养成良好的卫生习惯,增加纯母乳喂养对预防婴幼儿患HFMD起到保护性作用?

关 键 词:手足口病    危险因素
收稿时间:2011/12/17 0:00:00

Risk factors of hand-foot-mouth disease
ZHANG Wei-wei,LI Liang,MENG Fan-yue,LI Jing-xin,JI Hong,Dong Yu-ying,PAN Hong-xing,CHU Kai,XU Ke and ZHU Feng-cai.Risk factors of hand-foot-mouth disease[J].Acta Universitatis Medicinalis Nanjing,2012(4):495-499.
Authors:ZHANG Wei-wei  LI Liang  MENG Fan-yue  LI Jing-xin  JI Hong  Dong Yu-ying  PAN Hong-xing  CHU Kai  XU Ke and ZHU Feng-cai
Institution:Department of Epidemiology and Health Statistics,School of Publich Health,Southeast University,Nanjing 210009;Department of Infectious Disease Control,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Department of Infectious Disease Control,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Department of Infectious Disease Control,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Department of Infectious Disease Control,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Department of Epidemiology and Health Statistics,School of Publich Health,Southeast University,Nanjing 210009;Department of Infectious Disease Control,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Department of Infectious Disease Control,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Department of Infectious Disease Control,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Department of Infectious Disease Control,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China
Abstract:Objective:To explore risk factors of hand-foot-mouth disease (HFMD) in northern parts of Jiangsu province. Methods:Questionnaire survey was used to investigate the history of children with HFMD in past 3 years retrospectively in 6 counties belong to Yancheng and Huaian. Univariate analysis and multi-logistic regression analysis were used to analyze major risk factors of HFMD. Results: There were 170 HFMD cases in 1 239 study objects with incidence of 50.36/1000 person-years,with 153 outpatient and 17 inpatient cases. Univariate analysis indicated that five exposure factors were related to the occurrence of HFMD;Multivariate analysis showed that there were three risk factors and two protective factors concerned with the prevalence of HFMD,and the factors were depicted as follow:male(OR=1.60,95%CI:1.12-2.27),living in urban(OR=1.71,95%CI:1.15-2.53),children with frequent upper respiratory tract infection,diarrhea and so on (OR=1.96,95%CI:1.20-3.21),breastfeeding only for 3-6 months(OR=0.39,95%CI:0.17-0.84) and washing their hands before and after meals (OR=0.54,95%CI:0.36-0.81). Conclusion: In urban with large density of population,contact transmission was one way of HFMD infection,so reducing children to contact with the patient would be effective to control HFMD spread. In addition,developing good health habits and breastfeeding shoud protect infant and children from HFMD.
Keywords:HFMD  risk factors
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