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不同剂量HBIG联合乙肝疫苗阻断HBV母婴传播效果的随机对照研究
引用本文:孙 翔,翟祥军,朱凤才,许卫国,鲍倡俊,朱叶飞,卞 倩,殷晓梅,彭 红,朱立国,常宝龙,刘红建,刘黎静,张秋明,刘耀珍,李 杰,庄 辉,汪 华.不同剂量HBIG联合乙肝疫苗阻断HBV母婴传播效果的随机对照研究[J].南京医科大学学报,2012(4):491-494.
作者姓名:孙 翔  翟祥军  朱凤才  许卫国  鲍倡俊  朱叶飞  卞 倩  殷晓梅  彭 红  朱立国  常宝龙  刘红建  刘黎静  张秋明  刘耀珍  李 杰  庄 辉  汪 华
作者单位:南京医科大学公共卫生学院流行病与卫生统计学系,江苏 南京 210029;江苏省疾病预防控制中心重大科技项目办公室,江苏 南京 210009;江苏省疾病预防控制中心重大科技项目办公室,江苏 南京 210009;江苏省疾病预防控制中心重大科技项目办公室,江苏 南京 210009;江苏省疾病预防控制中心重大科技项目办公室,江苏 南京 210009;江苏省疾病预防控制中心重大科技项目办公室,江苏 南京 210009;江苏省疾病预防控制中心重大科技项目办公室,江苏 南京 210009;江苏省疾病预防控制中心重大科技项目办公室,江苏 南京 210009;江苏省疾病预防控制中心重大科技项目办公室,江苏 南京 210009;江苏省疾病预防控制中心重大科技项目办公室,江苏 南京 210009;东南大学公共卫生学院流行病与卫生统计系,江苏 南京 210009;泰兴市疾病预防控制中心急传科,江苏 泰兴 225400;泰兴市疾病预防控制中心急传科,江苏 泰兴 225400;楚州市疾病预防控制中心急传科,江苏 楚州 223200;楚州市疾病预防控制中心急传科,江苏 楚州 223200;北京大学医学部病原生物学系,北京 100088;北京大学医学部病原生物学系,北京 100088;江苏省疾病预防控制中心重大科技项目办公室,江苏 南京 210009
基金项目:国家科技重大专项资助(2008ZX10002-001, 2009ZX10004-904)
摘    要:目的:评价乙肝疫苗联合不同剂量乙型肝炎免疫球蛋白(hepatitis B immunoglobulin,HBIG)对HBV母婴阻断的效果,探讨有效经济的联合免疫阻断方法?方法:将HBsAg阳性母亲的新生儿随机分为100 IU HBIG免疫组和200 IU HBIG免疫组,分别在出生12 h内注射100 IU或200 IU HBIG,同时新生儿都按0?1?6的程序接种10 μg乙肝疫苗,在婴儿7个月龄时观察HBV母婴阻断效果?结果:100 IU?200 IU组母婴阻断成功率分别为98.3%?98.0%,两组的阻断效果无明显差异,结合母亲HBV感染状态分析,两组的阻断效果亦无明显差异?结论:在新生儿HBV母婴阻断中,100 IU HBIG或200 IU HBIG联合10 μg乙肝疫苗的主被动联合免疫可获相似的阻断效果?

关 键 词:乙肝  母婴阻断  联合免疫  危险因素

Comparing the efficacy of passive-active immunoprophylaxis using different doses of hepatitis B immunoglobulin in newborns of HBsAg positive mothers
SUN Xiang,ZHAI Xiang-jun,ZHU Feng-cai,XU Wei-guo,BAO Chang-jun,ZHU Ye-fei,BIAN Qian,YIN Xiao-mei,PENG Hong,ZHU Li-guo,CHANG Bao-long,LIU Hong-jian,LIU Li-jing,ZHANG Qiu-ming,LIU Yao-zhen,LI Jie,ZHUANG Hui and WANG Hua.Comparing the efficacy of passive-active immunoprophylaxis using different doses of hepatitis B immunoglobulin in newborns of HBsAg positive mothers[J].Acta Universitatis Medicinalis Nanjing,2012(4):491-494.
Authors:SUN Xiang  ZHAI Xiang-jun  ZHU Feng-cai  XU Wei-guo  BAO Chang-jun  ZHU Ye-fei  BIAN Qian  YIN Xiao-mei  PENG Hong  ZHU Li-guo  CHANG Bao-long  LIU Hong-jian  LIU Li-jing  ZHANG Qiu-ming  LIU Yao-zhen  LI Jie  ZHUANG Hui and WANG Hua
Institution:Department of Epidemiology and Biostatistics,School of Public Health,NJMU,Nanjing 210029;National Major Science Technology Projects Office,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009;National Major Science Technology Projects Office,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009;National Major Science Technology Projects Office,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009;National Major Science Technology Projects Office,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009;National Major Science Technology Projects Office,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009;National Major Science Technology Projects Office,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009;National Major Science Technology Projects Office,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009;National Major Science Technology Projects Office,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009;National Major Science Technology Projects Office,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009;Department of Epidemiology and Biostatistics,School of Public Health,Southeast University,Nanjing 210009;Office of Acute Infectious Disease,Taixing Municipal Center for Disease Control and Prevention,Taixing 225400;Office of Acute Infectious Disease,Taixing Municipal Center for Disease Control and Prevention,Taixing 225400;Office of Acute Infectious Disease,Chuzhou Municipal Center for Disease Control and Prevention,Chuzhou 223200;Office of Acute Infectious Disease,Chuzhou Municipal Center for Disease Control and Prevention,Chuzhou 223200;Department of Microbiology,Health Science Center of Peking University,Beijing 100088,China;Department of Microbiology,Health Science Center of Peking University,Beijing 100088,China;National Major Science Technology Projects Office,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009
Abstract:
Keywords:hepatitis B  blocking of mother to child transmission  passive-active immunoprophylaxis  risk factors
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