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人细胞色素P450 2A13基因在舌癌中的表达
引用本文:孙 莉,王丽薇,谭 宁,郭维杰,范才文.人细胞色素P450 2A13基因在舌癌中的表达[J].南京医科大学学报,2010(5):678-683.
作者姓名:孙 莉  王丽薇  谭 宁  郭维杰  范才文
作者单位:桂林医学院基础医学院生物技术学院;上海市肿瘤研究所;
基金项目:2005年教育部春晖计划基金资助(Z2005-2-45006)
摘    要:目的:比较分析细胞色素P4502A13(cytochrome P450 2A13,CYP2A13)分别在舌癌组织及其对应癌旁组织中的表达水平,探讨CYP2A13与舌癌的相关性。方法:采用实时定量PCR和Western blot技术分别检测26例舌癌组织及其对应癌旁组织中CYP2A13mRNA及蛋白表达。结果:CYP2A13 mRNA及蛋白在舌癌组织中表达量均低于对应的癌旁组织(P<0.05)。结论:CYP2A13在舌癌组织中表达降低,结合CYP2A13的功能,提示CYP2A13在癌组织中的表达降低可能是舌癌发生发展过程中的自我保护效应。

关 键 词:细胞色素P450  2A13  舌癌  实时定量PCR  蛋白印迹  
收稿时间:2009/7/24 0:00:00

Expression of cytochrome P450 2A13 gene in tongue cancer
SUN Li,WANG Li-wei,TAN Ning,GUO Wei-jie and FAN Cai-wen.Expression of cytochrome P450 2A13 gene in tongue cancer[J].Acta Universitatis Medicinalis Nanjing,2010(5):678-683.
Authors:SUN Li  WANG Li-wei  TAN Ning  GUO Wei-jie and FAN Cai-wen
Institution:College of Basic Medicine/a>;Biotechnology Institute/a>;Guilin Medical University/a>;Guilin 541004/a>;1Shanghai Cancer Institute/a>;Shanghai 200032/a>;China
Abstract:Objective:To analyze the relationship between the cytochrome P450 2A13(CYP2A13) gene and tongue cancer.Methods:CYP2A13 mRNA and protein were detected by real-time fluorescent quantitative PCR and western blot respecytively in 26 cases of oral cancer and their corresponding adjacent tissues.Results:CYP2A13 mRNA and protein were expressed in tongue cancer and their surroundings.And the expression of CYP2A13 mRNA and protein in tongue cancer is much lower than in their surroundings(P < 0.05).Conclusion:Down-re...
Keywords:cytochrome P450 2A13  tongue cancer  real-time PCR  western blot  
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