| 负性分子B7-H4在乳腺癌组织中的表达及其临床意义 |
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| 引用本文： | 虞培娟,朱 旬,严茹红,洪 荫,朱雪明,傅丰庆,张学光.负性分子B7-H4在乳腺癌组织中的表达及其临床意义[J].南京医科大学学报,2016(5):520-523. |
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| 作者姓名： | 虞培娟 朱 旬 严茹红 洪 荫 朱雪明 傅丰庆 张学光 |
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| 作者单位： | 苏州大学附属第二医院检验科,江苏 苏州 215004,苏州大学附属第二医院普外科,江苏 苏州 215004,苏州大学附属第二医院检验科,江苏 苏州 215004,苏州大学附属第二医院普外科,江苏 苏州 215004,苏州大学附属第二医院检验科,江苏 苏州 215004,苏州大学附属第一医院临床免疫研究所,江苏 苏州 215001,苏州大学附属第一医院临床免疫研究所,江苏 苏州 215001 |
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| 基金项目： | 国家自然科学基金(81301494) |
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| 摘 要： | 目的:探讨负性分子B7-H4在乳腺癌组织中的表达情况及其与临床病理参数之间的关系?方法:通过免疫组织化学技术分析68例乳腺癌组织和30例良性纤维瘤中B7-H4的表达情况,并结合临床资料统计分析B7-H4表达与乳腺癌患者临床特征之间的关系?结果:免疫组织化学结果显示,乳腺癌组织中B7-H4的阳性率为75%,明显高于纤维瘤组织(17%)(P < 0.05),并与雌激素受体(estrogen receptor,ER)表达呈负相关?与人类表皮生长因子2(human epidermal growth factor receptor2,HER-2)呈正相关,而在年龄?肿瘤大小?病理类型等其他变量之间不存在显著差异?结论:乳腺癌组织中B7-H4异常表达,与乳腺组织良性病变存在差异(P < 0.05),并与ER?HER-2的表达相关,提示B7-H4分子在乳腺癌的发生发展过程中起了重要作用?
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| 关 键 词： | B7-H4 乳腺癌 ER HER-2 |
| 收稿时间： | 1/3/2016 12:00:00 AM |
Expression and clinical significance of B7-H4 in breast cancer |
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| Yu Peijuan,Zhu Xun,Yan Ruhong,Hong Yin,Zhu Xueming,Fu Fengqing and Zhang Xueguang.Expression and clinical significance of B7-H4 in breast cancer[J].Acta Universitatis Medicinalis Nanjing,2016(5):520-523. |
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| Authors: | Yu Peijuan Zhu Xun Yan Ruhong Hong Yin Zhu Xueming Fu Fengqing and Zhang Xueguang |
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| Institution: | Department of Clinical Laboratory, the Second Affiliated Hospital of Soochow University,Suzhou 215004,Department of General Surgery, the Second Affiliated Hospital of Soochow University,Suzhou 215004,Department of Clinical Laboratory, the Second Affiliated Hospital of Soochow University,Suzhou 215004,Department of General Surgery, the Second Affiliated Hospital of Soochow University,Suzhou 215004,Department of Clinical Laboratory, the Second Affiliated Hospital of Soochow University,Suzhou 215004,Institute of Clinical Immunology, the First Affiliated Hospital of Soochow University,Suzhou 215001,China and Institute of Clinical Immunology, the First Affiliated Hospital of Soochow University,Suzhou 215001,China |
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| Abstract: | Objective:To discuss the expression of B7-H4 protein in breast cancer tissues as well as the relationship among clinical pathological parameters. Methods:Immunohistochemical technique was employed to investigate the expression of B7-H4 in 68 cases of breast cancer and 30 cases of benign fibroadenoma. And statistical analysis was carried out to study the relationship between B7-H4 and pathological parameters. Results:The B7-H4 positive rate of breast cancer was 75%,significantly higher than fibroadenoma tissues (17%)(P < 0.05). And highly expression of B7-H4 was negatively correlated to estrogen receptor (ER) but positively correlated to human epidermal growth factor 2 correlation (HER-2), independent from other factors such as age,size of tumor and clinical stage. Conclusion:Aberrant B7-H4 expression in breast cancer but not benign fibroadenoma implied that B7-H4 may play an important role in the development of breast cancer. |
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| Keywords: | B7-H4 breast cancer ER HER-2 |
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