糖尿病患者尿微量白蛋白与动脉硬化指数之间的关系

目的:探讨糖尿病患者动脉僵硬度与尿中微量白蛋白的关系,并对影响动脉硬化指数(arterial stiffness index, ASI)的因素进行初步探讨.方法:对入选的135例糖尿病患者,应用Cardio Vision MS-2000动脉硬度测量仪测定ASI,反映外周血管弹性.并对所有人选对象进行晨尿尿白蛋白/肌酐比值(albumin/creatinine ratio, ACR)测定,据结果分为增高、正常2组,应用统计学方法进行组间差异比较分析.并对影响ASI的因素进行探讨.结果:尿白蛋白/肌酐比值增高患者ASI明显高于正常组(P<0.01),2组之间年龄、收缩压(SBP)、脉压(PP)、高密度脂蛋白胆固醇(HDL-C)、肾小球滤过率(GFR)、糖化血红蛋白(HbA1C),以及糖尿病病程亦有明显差异(P<0.05).单因素相关分析显示,年龄、SBP、PP、低密度脂蛋白胆固醇(LDL-c)、GFR、HbA1C、尿白蛋白/肌酐比值、糖尿病病程与ASI明显相关(P<0.05).多因素逐步线性回归分析确定PP、HbA1C、尿白蛋白/肌酐比值以及糖尿病病程为ASI的独立影响因素.结论:糖尿病患者中,尿白蛋白/肌酐比值与应用ASI反应的血管硬化情况明显相关.

Arterial stiffness index and microalbuminuria in patients with type 2 diabetes

Objective:To investigate the relationship between microalbuminuria and arterial stiffness index in diabetes patients. Methods:A total of 135 patients with diabetes were studied. Arterial Stiffness Index(ASI) which can reflect large arterial compliance was measured by CardioVisionMS-2000 arterial stiffness detector. Albumin/creatinine ratio(ACR) was determined. Results:ASI was higher in high ACR group than in normal ACR group. There were significant differences in age,SBP,PP,HDL-C,GFR,HbA1C,duration of diabetes between two groups(P < 0.05). There was a positive correlation between age,SBP,PP,LDL-C,ACR,HbA1C,duration of diabetes and ASI showed by single factor correlation analysis methods(P < 0.05) However there was a negative correlation between GFR and ASI(P < 0.05). PP,ACR,HbA1C,duration of diabetes were independent risk factors of ASI showed by multiple linear stepwise regression analysis method. Conclusion:The artery compliance as measured by ASI is increased in patients with type 2 diabetes and raised ACR.