MIF-173位点单核苷酸多态性与影响前列腺癌预后因素关系的研究

目的:研究巨噬细胞移动抑制因子(macrophage migralion inhibitory factor,MIF)-173位点单核苷酸多态性与影响前列腺癌预后因素的关系。方法:应用聚合酶链反应限制性片段长度多态性(PCR-RFLP)分析259例前列腺癌患者MIF基因-173位点的多态性,比较不同基因型与前列腺癌患者的前列腺癌特异性抗原(PSA)、Gleason评分、临床分期的关系、结果:MIF-173 *C等位基因与PSA、Gleason评分、临床分期具有显著相关性(adjusted OR=4.39,10.73,15.68;95%CI:2.43～7.93,5.36～21.50,7.40～33.23)。结论:MIF-173*C等位基因可能与前列腺癌的预后有关,携带MIF-173*C等位基因的前列腺癌患者可能预后较差。

Association of polymorphisms in MIF-173 genotypes and prognosis factors of prostate cancer

Objective:To investigate the potential association between the polymorphisms in MIF-173 genotypes and prognosis factors(PSA value,Gleason score and clinical stage)of prostate cancer(PCa).Methods:The polymorphisms of MIF-173 sites were analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)technique using genomie DNA isolated from peripheral blood.The association between the prognosis faetors(PSA value,Gleason score and clinical stage)of PCa and different genotypes was evaluated.Results:The MIF-173*C variant allele was associated with higher PSA value of the PCa(adjusted OR= 4.39,95%CI:2.43-7.93).It was noted that the MIF-173*C variant allele was associated with higher Gleason score and later clinical stage of PCa patients(adjusted OR=10.73,95%CI:5.36-21.50adjusted OR=15.68,95%CI:7.40-33.23,respectively).Conclusion: The results demonstrated that the MIF-173 G to C variant influenced the PSA value,Gleason soccer and clinical stage of PCa.The MIF-173 G to C variant might have a joint effect on the risk of worse prognosis of PCa.