尿激酶型纤溶酶原激活物与胃癌侵袭及转移关系的研究

目的 :研究尿激酶型纤溶酶原激活物 ( u PA)与胃癌的侵袭及转移的关系。方法 :采用免疫组化 ABC法测定胃癌组织、癌旁组织、正常胃组织中 u PA的表达。结果 :胃癌组织中 u PA的表达明显高于癌旁组织和正常胃组织 ,P<0 .0 1;u PA的高表达与胃癌的浸润深度、淋巴结转移及淋巴结转移率、生长方式和分化程度密切相关 ,P<0 .0 1;与肿瘤大小无关 ,P>0 .0 5。阳性表达定位于胃癌组织的癌细胞胞质。结论 :u PA的高表达与胃癌的侵袭与转移密切相关。

The Study of the Relationship between the Expression of Urokinase-type Plasminogen Activator and Invasion and Metastasis of Human Gastric Cancer

Objective:To study the relationship between the expre ssion of urokinase type plasminogen activator (uPA) and invasion, metastasis of human gastric cancer. Methods:The expression of urokinase type pla sm inogen activator in cancer, cancer adjacent tissue and normal tissue was determ ined by immunohistochemistry. Results:The expression of uPA in cance r tissue was significantly higher than in cancer adjacent tissue and normal tissu e ( P<0 01) , and the expression of uPA was significantly associated with the depth of cancer invasion, the metastasis of lymph node, the rate of lymph node m etastasis, the growth pattern of cancer and the differentiation degree of cancer ( P<0 01) . The expression of uPA was not correlated with the size of cancer . The positive expression location was in the cytoplasm of cancer cell. Con clusion:The high expression of uPA might be significantly associated with invasion and metastasis of human gastric cancer.