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大黄酸对人前体脂肪细胞增殖与分化的影响
引用本文:袁小青,马向华,丁亚琴,王 芳,沈 捷.大黄酸对人前体脂肪细胞增殖与分化的影响[J].南京医科大学学报,2009,29(2):161-165.
作者姓名:袁小青  马向华  丁亚琴  王 芳  沈 捷
作者单位:袁小青,YUAN Xiao-qing(常州市中医院,江苏,常州,213003);马向华,丁亚琴,王芳,MA Xiang-hua,DING Ya-qin,WANG Fang(南京医科大学第一附属医院内分泌科,江苏,南京,210029);沈捷,SHEN Jie(南京医科大学第一附属医院中心实验室,江苏,南京,210029)  
摘    要:目的:研究大黄酸(rhein,Rh)对人前体脂肪细胞增殖与分化的影响,并进一步探讨其作用机制.方法:采用噻唑蓝(MTT)比色法测定RH对人前体脂肪细胞增殖的影响;通过形态学观察脂肪细胞的分化程度及形态学变化;并用油红O染色法,检测脂肪细胞内甘油三酯积聚量的变化;应用RT-PCR检测RH干预后分化抑制基因CHOP mRNA的表达.结果:各浓度组RH(0.1、1、2.5、5、10 ug/ml)抑制人前体脂肪细胞增殖,作用呈剂量依赖性;RH对脂肪细胞分化的抑制作用亦呈剂量依赖性;1 ug/ml的RH使CHOP mRNA表达增加.结论:RH可抑制人前体脂肪细胞增殖与分化,该作用可能与CHOP表达上调有关.

关 键 词:大黄酸  人前体脂肪细胞  增殖与分化
收稿时间:2008/10/13 0:00:00

Effects of Rhein on proliferation and differentiation of human preadipocytes
YUAN Xiao-qing,MA Xiang-hu,DING Ya-qin,WANG Fang and SHEN Jie.Effects of Rhein on proliferation and differentiation of human preadipocytes[J].Acta Universitatis Medicinalis Nanjing,2009,29(2):161-165.
Authors:YUAN Xiao-qing  MA Xiang-hu  DING Ya-qin  WANG Fang and SHEN Jie
Institution:Department of Endocrinology;1Central Laboratory;the First Affiliated Hospital of NJMU;Nanjing 210029;China
Abstract:Objective:To explore the effects of Rhein(RH) on proliferation and differentiation of human preadipocytes. Methods: Omental adipose tissue biopsies were obtained from 15 patients who were undergoing elective open-abdominal surgery. The primary culture and differentiation induction of human preadipocytes were performed, and the human preadipocytes were treated with rhein at different concentrations at proper moments. Dynamic morphological changes of the human preadipocytes were observed, and their proliferat...
Keywords:CHOP
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