血浆HSP70在血管性认知功能损害患者中的表达及意义

目的:探讨热休克蛋白70(HSP70)与血管性认知功能损害(VCI)的关系。方法:运用蒙特利尔认知评估量表(MoCA)检测入组患者认知功能,将其分为2组,即认知功能正常组(NCI,n=52)和VCI组(n=129),分别用酶联免疫吸附试验(ELISA)测定2组患者血浆HSP70浓度。结果:NCI组和VCI组患者血浆HSP70浓度分别为(11.29±2.66)ng/ml和(19.92±5.98)ng/ml,差异有统计学意义(P<0.01);相关性分析显示,VCI患者血浆HSP70浓度与MoCA得分呈负相关(r=-0.742,P<0.01);对VCI患者各个认知领域的分值与血浆HSP70水平进行多元线性回归分析显示,血浆HSP70水平与患者记忆能力、视空间执行能力和定向能力存在负相关性。结论:血浆HSP70浓度测定有可能作为判断VCI患者认知功能损害程度的生化指标。

Expression and significance of heat shock protein 70 in vascular cognitive impairment patients

Objective:To explore the relationship between heat shock protein 70(HSP70) and vascular cognitive impairment(VCI).Methods:181 patients were divided into not cognitively impaired (NCI,n=52)and VCI (n=129) groups.Cognitive function and serum HSP70 levels in two groups were tested by Montreal Cognitive Assessment(MoCA) and enzyme linked immunosorbent assay(ELISA),respectively. Results:The serum HSP70 levels in the NCI and VCI groups were 11.29±2.66 ng/ml and 19.92±5.98 ng/ml,respectively,and there were significant differences(P < 0.01).The correlation analysis revealed that the serum HSP70 levels were negatively correlated with the total MoCA scores(r=-0.742,P < 0.01);Multivariable linear regression showed that the seium HSP70 levels were also negatively correlated with the memory scores,the visuospatial/executive scores and the orientation scores in the VCI groups. Conclusions:HSP70 may be used as the biochemical indicator for observing vascular cognitive impairment.