经肝动脉碘油与无水酒精乳剂节段性栓塞的实验研究

目的：探讨经动脉肝节段性栓塞的可行性及实用价值。方法：选取新西兰兔18只、体重2．2～3．1kg，随机分为三组。导管分别插入至肝右和肝左动脉分支各7、11例。用超液化碘油与无水乙醇3种比例3：1、2：1和1：0的乳剂经微导管内缓慢注入，直至相应节段染色、门脉显现为止。术中观测兔的生命体征；术前、术后1、3、5、7天分别测定肝肾功能及外周血象，术后1～2周行肝动脉DSA后处死兔，观察栓塞肝段的病理变化。结果：3：1与2：1实验组大体标本及组织学检查示肝组织节段性灭活，肝肾功能检查结果及外周血象显示术前和术后第7天指标相比无明显变化。结论：超液化碘油与无水乙醇乳剂经肝动脉栓塞，方法可行、安全，可达到肝节段性组织灭活的效果．

Experimental Trial on Liver Segmental Embolization via Transarterial Route With Lipiodol and Ethanol Mixture

Objective: To investigate the possibility and practicality of liver segmental embolization (LSE) technique via transarterial route. Methods: Eighteen New Zealand white rabbits weighted from 2.2 to 3.1 kg were selected and divided into three groups at random. The branches of the right and left hepatic artery were entered with coaxial microcatheter technique in 7 and 11 rabbits. A mixture of Lipiodol Ultra Fluide /ethanol in ration of 3:1,2:1 and 1:0 was infused into the microcatheter until the liver segmental stain and portal vein revealed. All the vital signs were monitored intra-operatively and blood specimens were collected on day 0,1,3,5, and 7 days after LSE for the hepatic, renal function, and blood routine tests. After 1-2 weeks, rabbits were killed to observe the liver segmental pathological changes before hepatic artery DSA. Results:Pathological assay showed that liver segment ablated with the mixture (3:1 and 2:1) was coagulatively necrotic either grossly or microscopically 1-2 weeks after LSE. The hepatic, renal function, and blood routine returned to normal in all animals 7 days later. Conclusion: LSE with lipiodol and ethanol mixture is safe, effective and practical.