甲亢和甲减患者血清瘦素水平分析

目的：初步探讨瘦素与甲状腺疾病之间的联系，及其与垂体－甲状腺轴之间的相互作用，方法：正常对照组，甲亢、甲减患者清晨空腹取血，磁酶联免疫分析法和Serozyme I系统测定游离三碘甲状腺原氨酸（FT3），游离四碘甲状腺原氨酸（FT4），促甲状腺激素（TSH），瘦素水平采用DS珠酶免疫测定试剂盒，结果：与正常对照组相比，甲亢患者TSH显著降低，FT3，FT4显著升高，瘦素水平没有显著变化，甲减患者TSH显著升高，FT3，FT4显著降低，瘦素水平明显升高，男女两性的瘦素水平在正常组，甲亢组差异有显著性，而在甲减组差异不显著，结论：下丘脑－垂体－甲状腺轴和瘦素共同参与机体的进食，体重，能量代谢调节，血清瘦素水平与下丘脑－垂体－甲状腺轴的调节有关，与甲状腺疾病之间也存在着某种相关性。

Comparison of Serum Leptin Levels in the Patients with Hyper- and Hypothyroidism

Objective:To investigate the relationship between leptin and hypop hsis-thyroid axis,and the roles of leptin in the pathophysiology of thyroid di seases.Methods:Hyperthyroidism,hypothyroidism,and volunteers as control,were recruited in this study.Serum thyroid-stimulate hormone(TSH),free T3 and free T4(FT3 and FT4),were measured with the method of magnetic antibody immunoassay .Leptin level was measured with the method of EIA. Results:Compared with contro l group,serum level of TSH in the hyperthyroidism group was significantly low, FT3 and FT4 were significantly high,while there was no difference in serum leve l of leptin.Serum level of TSH in hypothyroidism group increased significantly , FT3 and FT4 decreased significantly. The serum level of leptin in hypothyroidis m group was significantly higher than that in the control group. In euthyroid an d hyperthyroid groups,there was significant difference between male and female of serum leptin,and no relations in hypothyroidism group. Conclusion:Hypothala mus-pituitary-thyroid axis and leptin play an important role in regulating ing estion,weight and energy metabolism.Our data suggested that there was a relatio nship between leptin and thyroid diseases,which confirmed the hypothesis that l eptin and Hypothalamus-pituitary-thyroid axis interacted on each other.