| Experimental study of natural hydroxyapatite/chitosan composite on reconstructing bone defects |
| |
| 作者姓名： | Hua Yuan Ning Chen Xiaoying Lv Buzhong Zheng |
| |
| 摘 要： | Objective:To study the possibility of natural hydroxyapatite/chitosan composite on repairing bone defects. Methods:We developed a natural hydroxyapatite/chitosan composite that could be molded into any desired shape. The powder component consists of natural hydroxyapatite, which is epurated from bone of pigs. The liquid component consists of malic acid and chitosan. Operations were performed on the left tibias of 15 white rabbits to create two square bone defects. One of the defects was reconstructed with the composite, while the other was not repaired and used as a blank control. Three of the animals were killed at the end of 2 weeks, 4 weeks, 8 weeks, 12 weeks and 16 weeks respectively and implants were evaluated anatomically and histologically. Results:No apparent rejection reaction was found, except for a mild inflammatory infiltration observed 2 weeks after surgery. Fibrous tissue became thinner 2～8 weeks after surgery and bony connections were detected 12 weeks after surgery. The new bone was the same as the recipient bone by the 16th postoperative week. Conclusion:The hydroxyapatite/chitosan composite has good biocompatibility and osteoconduction. It is a potential repairing material for clinical application.
|
| 关 键 词： | 羟基磷灰石 脱乙酰壳多糖 骨头缺损 生物相容性 |
| 收稿时间： | 2008/7/26 0:00:00 |
Experimental study of natural hydroxyapatite/chitosan composite on reconstructing bone defects |
| |
| Hua Yuan,Ning Chen,Xiaoying Lv,Buzhong Zheng.Experimental study of natural hydroxyapatite/chitosan composite on reconstructing bone defects[J].Acta Universitatis Medicinalis Nanjing,2008,28(6):372-375. |
| |
| Authors: | Hua Yuan Ning Chen Xiaoying Lv and Buzhong Zheng |
| |
| Institution: | [1]Institute of Stomatology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China [2]State Key Laboratory of Department of Biomedical Engineering, Southeast University, Nanjing 210096, Jiangsu Province, China |
| |
| Abstract: | Objective:To study the possibility of natural hydroxyapatite/chitosan composite on repairing bone defects. Methods:We developed a natural hydroxyapatite/chitosan composite that could be molded into any desired shape. The powder component consists of natural hydroxyapatite, which is epurated from bone of pigs. The liquid component consists of malic acid and chitosan. Operations were performed on the left tibias of 15 white rabbits to create two square bone defects. One of the defects was reconstructed with the composite, while the other was not repaired and used as a blank control. Three of the animals were killed at the end of 2 weeks, 4 weeks, 8 weeks, 12 weeks and 16 weeks respectively and implants were evaluated anatomically and histologically. Results:No apparent rejection reaction was found, except for a mild inflammatory infiltration observed 2 weeks after surgery. Fibrous tissue became thinner 2 -8 weeks after surgery and bony connections were detected 12 weeks after surgery. The new bone was the same as the recipient bone by the 16th postoperative week. Conclusion:The hydroxyapatite/chitosan composite has good biocompatibility and osteoconduction. It is a potential repairing material for clinical application. |
| |
| Keywords: | Hydroxyapatite Chitosan Bone defect Biocompatibility |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《南京医科大学学报》浏览原始摘要信息 |
| 点击此处可从《南京医科大学学报》下载免费的PDF全文 |
|
