| 平阳霉素碘油乳剂灌注犬肾动脉所致的血管损伤作用 |
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| 引用本文： | 孔伟东,陈〓勇,曾庆乐,王〓海,何晓峰,李彦豪.平阳霉素碘油乳剂灌注犬肾动脉所致的血管损伤作用[J].南京医科大学学报,2009,29(11):1538-1541. |
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| 作者姓名： | 孔伟东 陈〓勇 曾庆乐 王〓海 何晓峰 李彦豪 |
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| 作者单位： | 南京军区南京总医院放射科,江苏 南京〓210002;南方医科大学南方医院介入治疗科,广东 广州 510515;南方医科大学南方医院介入治疗科,广东 广州 510515;南京军区南京总医院病理科,江苏 南京〓210002;南方医科大学南方医院介入治疗科,广东 广州 510515;南方医科大学南方医院介入治疗科,广东 广州 510515 |
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| 摘 要： | 目的:观察经犬肾动脉灌注平阳霉素(PYM)和平阳霉素碘油乳剂(PLE)产生的肾血管损伤,以验证PLE对血管的栓塞作用?方法:29只雄性家犬分3组:假手术组?PYM组和PLE组?PYM组在药物灌注后1?7和14天取材,PLE组在1?3?7?14?28和56天取材,观察各组肾血管的病理改变?结果:PYM组药物灌注后1天表现为局灶性血管内膜轻度肿胀,以肾小球毛细血管袢为主;7天内膜肿胀减轻;14天内膜形态基本恢复正常?PLE组早期(1~7天),肾脏毛细血管袢和动脉中膜(以小叶间动脉和入球小动脉为主)纤维素样坏死,伴血栓形成和血管周围炎细胞浸润;后期(14~56天)以血管壁平滑肌增生和纤维化,管腔狭窄和闭塞为主;两组均对静脉损伤轻微?结论:PLE较单纯PYM对肾血管的损伤作用早且持久,可能作为一种新的末梢栓塞剂用于临床血管栓塞术?
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| 关 键 词： | 平阳霉素 碘油 肾脏 血管 病理变化 |
| 收稿时间： | 2009/5/12 0:00:00 |
Injury effects on kidney vessels after intraarterial infusion of pingyangmycin lipiodol emulsion in dogs |
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| KONG Wei-dong,CHEN Yong,ZENG Qing-le,WANG Hai,HE Xiao-feng and LI Yan-hao.Injury effects on kidney vessels after intraarterial infusion of pingyangmycin lipiodol emulsion in dogs[J].Acta Universitatis Medicinalis Nanjing,2009,29(11):1538-1541. |
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| Authors: | KONG Wei-dong CHEN Yong ZENG Qing-le WANG Hai HE Xiao-feng and LI Yan-hao |
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| Institution: | Department of Radiology,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002;Department of Radiotherapy,Southern Hospital Affiliated to Southern Medical University,Guangzhou 510515;Department of Radiotherapy,Southern Hospital Affiliated to Southern Medical University,Guangzhou 510515;Department of Pathology,Nanjing General Hospital of Nanjing Military command,PLA,Nanjing 210002,China;Department of Radiotherapy,Southern Hospital Affiliated to Southern Medical University,Guangzhou 510515;Department of Radiotherapy,Southern Hospital Affiliated to Southern Medical University,Guangzhou 510515 |
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| Abstract: | |
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| Keywords: | pingyangmycin lipiodol kidney vessel pathology |
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