| 非小细胞肺癌endocan?FLK-1的表达与血管生成相关性研究 |
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| 引用本文： | 万锦平,黄建安,穆传勇,刘 皓,鲁常青.非小细胞肺癌endocan?FLK-1的表达与血管生成相关性研究[J].南京医科大学学报,2009,29(1):28-31. |
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| 作者姓名： | 万锦平 黄建安 穆传勇 刘 皓 鲁常青 |
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| 作者单位： | 万锦平,黄建安,刘皓,鲁常青,WAN Jin-ping,HUANG Jian-an,LIU Hao,LU Chang-qing(常州市第一人民医院呼吸科,江苏,常州,213003);穆传勇,MU Chuan-yong(苏州大学附属第一医院呼吸科,江苏,苏州,215000)
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| 摘 要： | 目的:研究内皮细胞特异分子-1(endothelial cell specific-1,endocan)、血管内皮细胞生长因子受体(KDR/FLK-1)在非小细胞肺癌(NSCLC)中的表达及其临床意义.同时探讨endocan、FLK-1与非小细胞肺癌血管生成的相关性.方法:应用免疫荧光技术检测60例手术切除的肺癌组织、21例癌旁肺组织(距癌组织5 cm以上)中的endocan表达水平;免疫组化SP法检测FLK-1表达,并计数微血管密度(MVD).结果:endocan、FLK-1的表达在NSCLC组织中明显高于癌旁组织(P均<0.05);endocan、FLK-1的表达与NSCLC的淋巴结转移、TNM分期正相关(P均<0.05),而与NSCLC的组织学分类无关(P均>0.05);在NSCLC中MVD、endocan、FLK-1阳性表达组明显高于二者阴性表达组(P均<0.05);endocan、FLK-1在NSCLC中的表达呈正相关(r=0.888 9,P<0.05).结论:endocan、FLK-1在NSCLC组织的血管发生、进展等病理过程有重要作用.
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| 关 键 词： | 非小细胞肺癌 内皮细胞特异分子-1 血管内皮细胞生长因子受体 微血管密度 |
| 收稿时间： | 2008/9/24 0:00:00 |
The Expression of endocan and FLK-1 and their correlations with angiogenesis in non small cell lung cancer |
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| WAN Jin-ping,HUANG Jian-an,MU Chuan-yong,LIU Hao and LU Chang-qing.The Expression of endocan and FLK-1 and their correlations with angiogenesis in non small cell lung cancer[J].Acta Universitatis Medicinalis Nanjing,2009,29(1):28-31. |
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| Authors: | WAN Jin-ping HUANG Jian-an MU Chuan-yong LIU Hao and LU Chang-qing |
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| Institution: | Department of Respiratory Medicine;Changzhou First Hospital;Changzhou 213003;1Department of Respiratory Medicine;the First Affiliated Hospital of Suzhou University;Suzhou 215000;China |
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| Abstract: | Objective:To investigate the expression of endocan and FLK-1 in NSCLC, and to explore the correlation with angio- genesis and other clinical pathophysiological characteristics of NSCLC. Methods:The expression of endocan was detected by using immunofluorescence technique in 60 specimens of NSCLC and 21 specimens of adjacent non-cancerous tissues as control group. Im- munohistochemical S-P method was performed to estimate the expression of FLK-1 and MVD. Results:The endocan-positive rate was 78.33%(47 / 60) i... |
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| Keywords: | non-small cell lung cancer endocan kinase insert domain containing receptor/fetal liver kinase-1 microvessel density |
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