| Adipose tissue resistin gene expression in DIO and DR rats |
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| 作者姓名： | Yuanyuan Zhao Yuhui Ni Xirong Guo Haixia Gong Xia Chi Ronghua Chen |
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| 作者单位： | [1]Nanjing Red Cross Blood Center, Nanjing 2100031 [2]Department of Pediatrics, Center of Human Functional Genomics of Nanjing Medical University, Nanjing 210029, China |
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| 基金项目： | 中国科学院资助项目;江苏省自然科学基金 |
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| 摘 要： | Objective： To investigate the expression of resistin gene in diet-induced obesity （DIO） and diet resistance （DR） rats. Methods： DIO and DR models were prepared with male SD rats after 6 weeks feeding by a diet of relatively high fat, sucrose, and caloric content （HE diet）. Body-weight, fat mass, and the concentration of serum insulin were measured, and the expression of resistin and Peroxisome proliferator-activated receptory-7（PPAR-7） gene in whit adipose tissue （WAT） was also detected by RT-PCR. Results： ① Body weight, fat mass and the concentration of serum insulin were significantly increased in DIO rats and decreased in DR rats. ② The expression of resistin and PPAR7 gene was upregulated in DIO group and supressed in DR group, but the expression of resistin was not detectable in all samples within three groups. Conclusion： Resistin may serve as a link between obesity and insulin resistance, but the individual difference is enormous.
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| 关 键 词： | 脂肪组织 抵抗素 基因表达 饮食调节 |
| 收稿时间： | 2005-09-05 |
Adipose tissue resistin gene expression in DIO and DR rats |
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| Yuanyuan Zhao,Yuhui Ni,Xirong Guo,Haixia Gong,Xia Chi,Ronghua Chen.Adipose tissue resistin gene expression in DIO and DR rats[J].Acta Universitatis Medicinalis Nanjing,2006,20(1):26-29. |
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| Authors: | Yuanyuan Zhao Yuhui Ni Xirong Guo Haixia Gong Xia Chi Ronghua Chen |
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| Abstract: | Objective: To investigate the expression of resistin gene in diet-induced obesity (DIO) and diet resistance (DR)rats. Methods: DIO and DR models were prepared with male SD rats after 6 weeks feeding by a diet of relatively high fat, sucrose, and caloric content (HE diet). Body-weight, fat mass, and the concentration of serum insulin were measured, and the expression of resistin and Peroxisome proliferator-activated receptory-γ(PPAR-γ) gene in whit adipose tissue (WAT) was also detected by RT-PCR. Results: ①Body weight, fat mass and the concentration of serum insulin were significantly increased in DIO rats and decreased in DR rats. ② The expression of resistin and PPARγ gene was upregulated in DIO group and supressed in DR group, but the expression of resistin was not detectable in all samples within three groups. Conclusion: Resistin may serve as a link between obesity and insulin resistance, but the individual difference is enormous. |
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| Keywords: | obesity DIO DR resistin insulin resistance |
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