| 哮喘患儿CD4+CD25+调节性T细胞及FOXP3的表达 |
| |
| 引用本文： | 史 彧,褚莉莉,张兰芳,赵德育.哮喘患儿CD4+CD25+调节性T细胞及FOXP3的表达[J].南京医科大学学报,2009,29(1):117-119. |
| |
| 作者姓名： | 史 彧 褚莉莉 张兰芳 赵德育 |
| |
| 作者单位： | 南京医科大学附属南京儿童医院呼吸科,江苏,南京,210008
|
| |
| 基金项目： | 南京医科大学科技发展基金 |
| |
| 摘 要： | 目的:研究CD4+CD25+调节性T细胞在哮喘儿童外周血中的比例改变,并探讨其临床意义.方法:采用细胞内染色的流式细胞术检测急性发作期哮喘患儿外周血CD4+CD25+Treg及其调控基因FOXP3的表达,并与健康对照组进行比较.结果:急性发作期哮喘患儿外周血CD4和CD25双阳性细胞所占比例与健康对照组无明显差异(P>0.05),而CD4+CD25+FOXP3调节性T细胞在外周血中的比例明显低于健康对照组(P<0.01).结论:哮喘患儿外周血CD4+CD25+FOXP3调节性T细胞在外周血中的比例明显减少,可能与哮喘的发病机制有关.
|
| 关 键 词： | CD4 CD25 调节性T细胞 哮喘 流式细胞术 |
Role of CD4+CD25+ regulation cells and expressing of FOXP3 in the pathogenesis of children with asthma |
| |
| SHI Yu,CHU Li-li,ZHANG Lan-fang and ZHAO De-yu.Role of CD4+CD25+ regulation cells and expressing of FOXP3 in the pathogenesis of children with asthma[J].Acta Universitatis Medicinalis Nanjing,2009,29(1):117-119. |
| |
| Authors: | SHI Yu CHU Li-li ZHANG Lan-fang and ZHAO De-yu |
| |
| Abstract: | Objective:To investigate the change of CD4+CD25+ T regulation cells in peripheral blood in children with asthma. Methods:CD4+CD25+FOXP3 T regulate cells in children with asthma were measured by intracellular 3-colour flow cytometry in peripheral blood cells in children with asthma. Results:There were similar frequencies of CD4+CD25+ T cells in peripheral blood of asthma children and health control. However, the quantity of CD4 +CD25 +FOXP3 T regulate cells was decreased significantly in peripheral blood of ... |
| |
| Keywords: | FOXP3 |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《南京医科大学学报》浏览原始摘要信息 |
| 点击此处可从《南京医科大学学报》下载免费的PDF全文 |
