2008~2011年鲍曼不动杆菌科室分布和耐药性变迁分析

目的:对南京医科大学第一附属医院2008~2011年鲍曼不动杆菌的分布情况及耐药性进行分析,指导临床合理用药?方法:采用VITEK2全自动微生物鉴定系统或API细菌鉴定板条进行菌种鉴定?用纸片琼脂扩散法(Kirby-Bauer法)进行药敏试验?Whonet 5.6 软件进行数据分析?结果:鲍曼不动杆菌在痰标本中所占比例最高,达到80.0%?该菌检出率较高的科室是老年医学科?重症监护病房?急诊科?呼吸科和脑外科?2008年鲍曼不动杆菌对头孢哌酮/舒巴坦?亚胺培南?美洛培南的耐药率分别为12.0%?14.8%?23.3%;而2011年的耐药率分别上升至67.4%?90.8%?91.1%?结论:鲍曼不动杆菌对临床常用药物的耐药性呈上升趋势,应加强耐药监控,控制其传播?

Changes of department distribution and antimicrobial agents resistance among Acineto-bacter baumannii isolated during 2008 to 2011

Objective:For guiding the clinical therapy,we sought to analyze the changing of department distribution and the resistance of Acinetobacter baumannii from the First Affiliated Hospital of NJMU during 2008 to 2011 Methods:The bacteria were identified by VITEK2 identification system or API bacterial identification strip. Antimicrobial susceptibility testing were carried out by the disc diffusion method (Kirby-Bauer method). Data analyses were performed by Whonet 5.6 software. Results:Acinetobacter baumannii ranked the highest proportion (80.0%) in sputum samples. The bacteria was detected in some clinical departments,including geriatrics,ICU,emergency department,respiratory and neurosurgery. The resistance rates to cefoperazone/sulbactam,imipenem and meropenem among Acinetobacter baumannii in 2008 were 12.0%,14.8% and 23.3%,respectively;while the resistance rates in 2011 increased to 67.4%,90.8% and 91.1%,respectively. Conclusion:We found that the resistance rates of many clinical used antimicrobial agents significantly increased in Acinetobacter baumannii isolates. We should pay attention to the antimicrobial resistance monitoring and control its spread.