| 花生四烯酸对小鼠卵泡衰老的影响 |
| |
| 引用本文： | 张 怡,李晓曦,林 艳,毕欣耘,于鹏丽,赵子建.花生四烯酸对小鼠卵泡衰老的影响[J].南京医科大学学报,2014(9):1202-1205. |
| |
| 作者姓名： | 张 怡 李晓曦 林 艳 毕欣耘 于鹏丽 赵子建 |
| |
| 作者单位： | 南京医科大学基础医学院代谢疾病研究中心,江苏 南京 210029;南京医科大学基础医学院代谢疾病研究中心,江苏 南京 210030;南京医科大学基础医学院代谢疾病研究中心,江苏 南京 210031;南京医科大学基础医学院代谢疾病研究中心,江苏 南京 210032;南京医科大学基础医学院代谢疾病研究中心,江苏 南京 210033;南京医科大学基础医学院代谢疾病研究中心,江苏 南京 210034 |
| |
| 基金项目： | 国家重大科学研究计划(2013CB945200):国家自然科学基金面上项目 (81170780,81372798,81200570);教育部博士学科点基金(20113234110005);江苏省科技支撑计划(BE2012756);江苏省自然科学基金(BK20130059,BK2011766) |
| |
| 摘 要： | 目的:研究花生四烯酸(arachidonic acid,AA)对小鼠卵泡发育的影响,探讨AA与卵巢早衰的关系?方法:10% AA饲料喂食4周龄ICR雌鼠,4个月后观察小鼠子宫卵巢重量?卵巢组织脂肪酸分析?卵巢组织学改变?结果:10%AA组与对照组相比子宫卵巢体重下降;脂肪酸分析结果显示10%AA组卵巢n-6/n-3不饱和脂肪酸比值增大;光镜下,10%AA组可见卵巢退行性黄体增多?间质纤维化?卵巢闭锁卵泡所占比例增加?结论:喂食10%AA饲料可引起小鼠卵巢衰老?
|
| 关 键 词： | 多不饱和脂肪酸 卵巢早衰 颗粒细胞 卵泡膜细胞 |
| 收稿时间： | 2014/3/17 0:00:00 |
Effects of arachidonic acid on follicle failure of mice |
| |
| Zhang Yi,Li Xiaoxi,Lin Yan,Bi Xinyun,Yu Pengli and Zhao Zijian.Effects of arachidonic acid on follicle failure of mice[J].Acta Universitatis Medicinalis Nanjing,2014(9):1202-1205. |
| |
| Authors: | Zhang Yi Li Xiaoxi Lin Yan Bi Xinyun Yu Pengli and Zhao Zijian |
| |
| Institution: | Metabolic Disease Research Center,School of Basic Sciences,NJMU,Nanjing 210029,China;Metabolic Disease Research Center,School of Basic Sciences,NJMU,Nanjing 210030,China;Metabolic Disease Research Center,School of Basic Sciences,NJMU,Nanjing 210031,China;Metabolic Disease Research Center,School of Basic Sciences,NJMU,Nanjing 210032,China;Metabolic Disease Research Center,School of Basic Sciences,NJMU,Nanjing 210033,China;Metabolic Disease Research Center,School of Basic Sciences,NJMU,Nanjing 210034,China |
| |
| Abstract: | Objective:To investigate the effect of arachidonic acid (AA) on follicle development of female mice and explore the relationship between AA and premature ovarian failure. Methods:ICR female mice of 4-week-old were fed with 10% AA. The weight of uterus and ovary,fatty acid analysis of ovaries,histological changes in ovaries were examined after four months. Results:The uterus and ovary weight of the 10% AA group were lower than those of the control group. Fatty acid analysis showed that the n-6/n-3 ratio of ovaries was increased in the 10% AA group. Under optical microscope,ovaries from the 10% AA group showed increased visible ovarian degenerative corpus luteum,interstitial fibrosis and increased proportion of atretic follicles. Conclusion:10% AA can cause obvious ovarian failure in mice. |
| |
| Keywords: | polyunsaturated fatty acid premature ovary failure granular cell theca cells |
|
| 点击此处可从《南京医科大学学报》浏览原始摘要信息 |
| 点击此处可从《南京医科大学学报》下载免费的PDF全文 |
|
