| 去势大鼠睾丸间质细胞移植的实验研究 |
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| 引用本文： | 张炜,吴婷.去势大鼠睾丸间质细胞移植的实验研究[J].南京医科大学学报,2002,22(6):468-469,539,F002. |
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| 作者姓名： | 张炜 吴婷 |
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| 作者单位： | 南京医科大学第一附属医院泌尿外科 江苏南京210029
(张炜)，南京医科大学第一附属医院泌尿外科 江苏南京210029(吴婷) |
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| 基金项目： | 江苏省教委科研基金资助项目(98KJD320010) |
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| 摘 要： | 目的：探讨对去势大鼠动物模型行睾丸间质细胞（Leydig细胞）移植的可行性。方法：随机选择SD大鼠离体睾丸进行Leydig细胞的体外培养及同种异体去势鼠大腿内侧肌群Leydig细胞移植，并进行绒毛膜促性腺激素（hCG)激发试验，监测其血清睾酮分泌情况的变化，结果：体外培养的Leydig细胞对hCG的刺激敏感，能分泌大量睾酮，而一旦进入机体后虽然短期内仍然成活，但分泌功能明显受阻，结论：通过施行同种异体睾丸Leydig细胞移植以提高血清睾酮含量的前景值得商榷。
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| 关 键 词： | 去势大鼠 睾丸 间质细胞移植 实验研究 |
| 文章编号： | 1007-4368(2002)06-0468-03 |
Experimental Study on Allografts of Leydig Cells in Castrated Rats |
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| ZHANG Wei,WU Ting.Experimental Study on Allografts of Leydig Cells in Castrated Rats[J].Acta Universitatis Medicinalis Nanjing,2002,22(6):468-469,539,F002. |
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| Authors: | ZHANG Wei WU Ting |
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| Abstract: | Objective:To investigate the feasibility of leydig cells thansplantation in castrated SD rat. Methods:Leydig cells of youth rat testes were cultured in vitro and transplanted into the vastus medialis of rats. hCG as a stimulant was injected and serum testosterone in rats was monitored after implantation. Results:leydig cells cultured in vitro were susceptible to stimulation of hCG and could secrete a large numbers of testosterone. After transplantation,their secreting function was obstructive hampered although they still surrived in a short time. Conclusion:Leydig cells transplantation could not increase the secretion of testosterone in castrated rats obviously and this method needs deliberation. |
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| Keywords: | leydigcells testosterone transplantation hCG |
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