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大鼠双侧供肾移植模型的建立
引用本文:冯宁翰,钱立新,华立新,郑峻松,宋宁宏,眭元庚,张炜,吴宏飞.大鼠双侧供肾移植模型的建立[J].南京医科大学学报,2005,25(8):521-523,543.
作者姓名:冯宁翰  钱立新  华立新  郑峻松  宋宁宏  眭元庚  张炜  吴宏飞
作者单位:[1]南京医科大学第一附属医院泌尿外科肾移植中心,江苏南京210029 [2]第三军医大学西南医院全军烧伤研究所、重庆市器官移植基础研究所,重庆400038
基金项目:国家自然科学基金资助项目(30200264),国家自然科学基金资助重大项目(39993430-2)
摘    要:目的:首创了一种可以同时取供体的双肾作供肾的大鼠肾移植模型。方法:以近交系Brown-Norway大鼠和近交系Lewis大鼠作为供、受体,取供体的双肾作为供肾,借助静脉支架管,行供体的静脉与受体肾静脉的端端吻合,肾动脉与腹主动脉行端侧吻合。结果:手术均于60min内完成。所有的受体均存活超过7天,围手术期死亡数为0。结论:首创双侧供肾大鼠肾移植模型是一种节省、可靠、实用的大鼠肾移植模型。

关 键 词:大鼠  肾移植  模型
文章编号:1007-4368(2005)08-0521-04

Establishment of the kidney transplantation model in rats :two renal allografts harvested from one donor
FENG Ning-han,QIAN Li-xin,HUA Li-xin,ZHENG Jun-song,SONG Ning-hong,SUI Yuan-geng,ZHANG Wei,WU Hong-fei.Establishment of the kidney transplantation model in rats :two renal allografts harvested from one donor[J].Acta Universitatis Medicinalis Nanjing,2005,25(8):521-523,543.
Authors:FENG Ning-han  QIAN Li-xin  HUA Li-xin  ZHENG Jun-song  SONG Ning-hong  SUI Yuan-geng  ZHANG Wei  WU Hong-fei
Institution:FENG Ning-han,QIAN Li-xin,HUA Li-xin,ZHENG Jun-song,SONG Ning-hong,SUI Yuan-geng,ZHANG Wei,WU Hong-fei*
Abstract:Objective: To establish an economical and feasible rat renal trans plantation model. Methods: Inbred Brown-Norway and Lewis mice were used as the d onors and the recipients. Both kidneys were removed from the donors. With the h elp of PTCA tube, an end-to-end anastomosis of vein was operated. Results: All operations were finished within 60 min. No one recipient died during operatio n period. Conclusion: The newly established method is feasible and reliable.
Keywords:rats  kidney transplantation  model
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