| 慢性HBV感染患者HBsAg亚型分析 |
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| 引用本文： | 黄祖瑚,韩亚萍.慢性HBV感染患者HBsAg亚型分析[J].南京医科大学学报,1997,17(2):115-118. |
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| 作者姓名： | 黄祖瑚 韩亚萍 |
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| 作者单位： | 南京医科大学第一附属医院传染病科 |
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| 基金项目： | 日本文部省国际学术研究基金 |
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| 摘 要： | 对包括慢性肝炎、肝炎肝硬变和原发性肝癌在内的１００例慢性ＨＢＶ感染者作了ＨＢｓＡｇ亚型分析。结果显示，在这组病例中ａｄｒ亚型占６１％，ａｄｗ占３３％，ａｙｒ占２％，ａｄｗｒ占４％。ａｄｒ亚型有随年龄增长更占优势的趋向。ａｄｒ和ａｄｗｒ亚型感染者ＨＢｓＡｇ滴度较ａｄｗ组显著增高，且ｅ抗原阳性率亦较高。上述发现提示，具有ａｄｒ和ａｄｗｒ亚型的ＨＢＶ株可能具有较强的复制活性，不易被清除，从而导致受感染者
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| 关 键 词： | 乙型肝炎病毒 表面抗原 亚型 慢性肝炎 |
Analysis of HBsAg Subtyoes Among Patients with Chronic HBV Infection |
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| Huang Zuhu,Han Yaping,Liu Ting,et al.Analysis of HBsAg Subtyoes Among Patients with Chronic HBV Infection[J].Acta Universitatis Medicinalis Nanjing,1997,17(2):115-118. |
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| Authors: | Huang Zuhu Han Yaping Liu Ting |
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| Institution: | Huang Zuhu,Han Yaping,Liu Ting,et al Department of Infections Diseases,The First Affiliated Hospital of Nannjing Medical University,Nanjing 210029 |
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| Abstract: | HBsAg subtypes were analysed in 100 patients with chronic HBV infection including chronic hepatitis, hepatitis liver cirrhosis and primary hepatocellular carcinoma. The results showed that among these patients the distributions of HBsAg subtypes were adr(61%),adw(33%),ayr(2%)and adwr(4%). There seems a tendency of HBsAg/adr gradually predominating over HBsAg/adw with increasing age. Patients with HBsAg/adr and HBsAg/adwr had HBsAg titres significantly higher than those with HBsAg/adw and also had rather high positive prevalence of HBeAg. These findings sugges that HBV strains with HBsAg/adr and HBsAg/adwr may possess higher replicative activities and hard to eradicate and consequently result in persistence of HBV infection. |
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| Keywords: | HBsAg subtype chronic hepatitis liver cirrhosis primary hepatocellular carcinoma |
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