江苏省男男性行为人群人类免疫缺陷病毒感染者潜伏期及其影响因素研究

目的:探讨江苏男男性行为人群人类免疫缺陷病毒(HIV)感染的潜伏期及其影响因素?方法:采用双向性队列研究,选择江苏省南京和镇江两市有明确HIV感染时间?经男男性接触途径感染艾滋病(AIDS)的病例,应用Kaplan-Meier乘积极限法计算潜伏期,用COX回归模型探讨AIDS发病的影响因素?结果:本次调查观察到男男性行为人群HIV感染者的平均潜伏期为(46.129 ± 2.795)个月,95%可信区间为40.651~51.606个月,多因素COX回归分析显示,基线CD4?半年CD4值较高是延迟进入AIDS发病期的保护因素?结论:江苏省男男性行为人群潜伏期短于国内外既往文献报道经其他途径传播的AIDS潜伏期,建议在有条件的情况下对男男性行为人群提供相应的卫生服务,通过早期治疗,延长其生存时间,提高生存质量?

A study on the HIV incubation period and its influencing factors among MSM of Jiangsu

Objective:To explore the incubation period and the influencing factors of HIV infection among men who have sex with men(MSM) in Jiangsu. Methods:An ambispective cohort study was conducted to collect a HIV infection and AIDS cases in two cities in Jiangsu Province with certain time mark of infected and onset. The average incubation period was calculated by Kaplan-Meier product-limited method. Cox regression model was used to explore the influencing factors. Results:The average incubation period of HIV infection was(46.129 ± 2.795) months,95%CI was 40.651-51.606 months,among MSM with HIV/AIDS through homosexual transmission in Jiangsu. COX proportional hazards regression model showed that higher CD4 counts at baseline and 6 months after diagnosis were the protective factors of incubation period. Conclusion:Incubation period of homosexual transmission AIDS may be lower than that of other previously reported data. The present study suggested that it was important for public halth service institutes to provide proper service for the early treatment of MSM infectors to prolong their survival time and to improve their survival quality.