加速型肾小球硬化动物模型的建立

目的 建立一种病变稳定、制作周期短、重复性好、最接近人类肾小球硬化病理改变的动物模型。方法 在摘除一侧肾脏的基础上，通过两次尾静脉注射柔红霉素，定期观察血、尿及肾脏组织病理学改变。结果 模型组大鼠于用药后第４周时，出现水肿、大量蛋白尿、低蛋白血症、高脂血症，病理形态上开始出现典型的节段性肾小球硬化；第９周时血清肌酐、尿素氮水平显著升高（Ｐ〈０．０５），８０％的肾小球出现节段性硬化。结论 此模型制作

Modified Animal Model of Rapid Glomerulosclerosis

To prepare an animal model which is stable on the pathological changes. The preparation of the animal model is easy and rapid, and is close to the human's glomerulosclerosis in pathology.Methods After excise a kidney, daunomycin was injected into rat's tail vein twice. The changes of their serum, urine and pathological changes was evaluated. Results The rats had edema, heavy proteinuria, hypoproteinemia, hypercholesterolemia and typical glomerular segmental sclerosis in pathology in the fourth week. in the ninth week, the BUN and creatinine lev el significantly increased (P<0.05) ,and the rate of ginmerulosclerosis raised to 80%Conclusion That daunomycin animal model can be used as an experimental mode of glomerulosclerosis, and the rapid preparation is one of its best advantages.