兔肝Vx2转移瘤模型的建立及影像学表现

目的：研究肝Vx2转移瘤模型的建立及磁共振(MR)、数字减影血管造影(DSA)的影像学表现，以便指导介入治疗：方法：新西兰兔20只，Vx2瘤块剖腹接种于兔肝左叶，2～3周后行MR扫描、DSA造影。结果：剖腹探查15只(75．0％)接种成功。MR扫描T，加权像(T1WI)为低信号，T2加权像(T2WI)为不均高信号；肝动脉造影肿瘤富血供，表现为肿瘤血管增粗紊乱、大量细小的异常血管、肿瘤染色(以周边染色为主)等，有2例肿瘤血管造影未见明显异常。结论：兔肝Vx2转移瘤模型是导管技术以及肝癌介入治疗研究，如栓塞、冷冻、微波、射频等较理想的动物模型，MR、DSA有利于实验动物的选择和治疗。

Preparing Rabbit Model with Hepatic Metastasis of Vx2 Carcinoma and Its Manifestation in the Image Examination

Objective:To prepare an animal model of hepatic metastasis of Vx2 carcinoma usher in rabbits,and evaluate its MR and DSA imaging in order to guide interventional therapy. Methods: Sixteen New Zealand white rabbits were implanted with Vx2 tumor in the left lobe of liver. MRJ and DSA were performed after 2-3 weeks. Results: Fifteen(?5. 0% ) rabbits were successfully inoculated. On MR scanning the tumors were seen as hypointensity on TiWI and uneven hyperintensity on T2WI. Hepatic angiography showed that the carcinomas had hypervascularity with disordered neovascularity and/or tumor stainCmainly around the tumor) . No obvious abnormality was shown in two hepatic angiography. Conclusion: The rabbit model with hepatic metastasis of Vx2 carcinoma is more suitable for investigation of catheterization and interventional therapies such as embolization, cyotherapy, microwave and radiofrequency therapy. MR and DSA were of benefits to the choice and therapy of experimental animals.