| P 物质对经典递质引起回肠纵行肌收缩效应的影响 |
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| 引用本文： | 肖强,李栋生,戴义隆,葛志恒.P 物质对经典递质引起回肠纵行肌收缩效应的影响[J].南京医科大学学报,1987(4). |
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| 作者姓名： | 肖强 李栋生 戴义隆 葛志恒 |
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| 作者单位： | 生理学研究室
(肖强，李栋生，戴义隆)，生理学研究室(葛志恒) |
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| 摘 要： | P 物质(Sp)能引起大鼠回肠纵行肌收缩并呈剂量依赖性。阈上剂量的Sp(10~(-7)M)可以增强Ach、5-HT 的收缩效应;减弱或消除NE 的抑制效应,阈下剂量的Sp(5×10~(-7)M)可以加强5-HT 的收缩效应,但对Ach、NE 无明显影响。结果提示:SP 可能作为兴奋性递质与经典递质一道共同调节消化道的运动,同时,Sp 对5-HT 可能还具有某种调制作用。
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| 关 键 词： | P 物质 乙酰胆硷 5-羟色胺 去甲肾上腺素 剂量效应关系 药物 肌收缩 回肠 白鼠 |
INFLUENCE OF SUBSTANCE P ON THE RESPONSES OF LONGITUDINAL MUSCLE OF RAT ILEUM TO CLASSICAL TRANSMITTERS |
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| Xiao Qiang,et at..INFLUENCE OF SUBSTANCE P ON THE RESPONSES OF LONGITUDINAL MUSCLE OF RAT ILEUM TO CLASSICAL TRANSMITTERS[J].Acta Universitatis Medicinalis Nanjing,1987(4). |
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| Authors: | Xiao Qiang et at |
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| Abstract: | The stimulating effect of Substance P(SP)on the longitudinal muscle
layer of the rat ileum was observed.SP could(1)potentiate the contractile
responses induced by Ach,5-HT and(2)attenuate or abolish the inhibitory
reponse induced by NE.We also found that subthreshold concentration of SP
could potentiate the effect of 5-HT,but had no influence on Ach or NE.It
suggested that SP,as an excitatory transmitter,might regulate the gastroin-
testinal motility with classical transmitters and modulate the affect of 5-HT. |
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| Keywords: | substance P acetylcholine 5-HT norepinephrine dosedesponse relationship drug muscle contraction ileum rats |
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