| 溃克灵对溃疡性结肠炎模型大鼠血清IL-8含量的影响 |
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| 引用本文： | 周红光,陈海彬,徐肇敏,于成功.溃克灵对溃疡性结肠炎模型大鼠血清IL-8含量的影响[J].南京医科大学学报,2009,29(4):488-490. |
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| 作者姓名： | 周红光 陈海彬 徐肇敏 于成功 |
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| 作者单位： | 周红光,陈海彬,ZHOU Hong-guang,CHEN Hai-bin(南京中医药大学第一临床医学院中西医结合系,江苏南京,210029);徐肇敏,于成功,XU Zhao-min,YU Cheng-gong(南京大学医学院附属鼓楼医院消化科,江苏南京,210008)
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| 基金项目： | 南京市卫生局医学科技重点课题 |
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| 摘 要： | 目的:建立溃疡性结肠炎(UC)大鼠模型,研究溃克灵(KKL)对大鼠溃疡性结肠炎的治疗作用及对血清白细胞介素-8(IL-8)产生和表达的影响,探讨KKL防治溃疡性结肠炎的作用机制.方法:采用2,4,6-三硝基苯磺酸(TNBS)法(100 mg/kg TNBS+50%的乙醇0.25ml)灌肠复制出溃疡性结肠炎大鼠模型.将72只大鼠随机分为正常组、模型组、柳氮磺吡啶(SASP)组、KKL大、中、小剂量组,观察结肠大体形态损伤、组织学变化,ELISA法测定各组大鼠血清IL-8水平.结果:与模型组相比,KKL各组、SASP组结肠大体形态损伤、组织学变化显著改善,血清IL-8水平显著降低(P<0.01).结论:溃克灵对大鼠UC有显著的治疗作用,抑制促炎因子IL-8的产生和表达可能是其治疗机制之一.
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| 关 键 词： | 溃克灵 溃疡性结肠炎 中药 白细胞介素-8 |
| 收稿时间： | 2008/10/31 0:00:00 |
Effects of kuikeling on IL-8 levels in the serum of rats with ulcerative colitis |
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| ZHOU Hong-guang,CHEN Hai-bin,XU Zhao-min and YU Cheng-gong.Effects of kuikeling on IL-8 levels in the serum of rats with ulcerative colitis[J].Acta Universitatis Medicinalis Nanjing,2009,29(4):488-490. |
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| Authors: | ZHOU Hong-guang CHEN Hai-bin XU Zhao-min and YU Cheng-gong |
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| Institution: | Nanjing University of Traditional Chinese Medicine;Nanjing 210029;1Department of Gastroenterology;Drum Tower Hospital Affiliated to Medied School of Nanjing University Nanjing 210008;china |
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| Abstract: | Objective:To study the effects of Kuikeling(KKL) on IL-8 levels in the serum of rats with ulcerative colitis and to research them mechanism for repairing these ulcers.Methods:Ulcerative colitis model was established by TNBS method.Total of 72 rats were randomly divided into 6 groups:normal group,model group,KKL large,medium,and little dose groups,SASP group.Colon mucosal inflammation and damage were assessed by mucosal lesion area and histological damage scores.Levels of serum interleukin-8(IL-8) were detec... |
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| Keywords: | Kuikeling ulcerative colitis traditional Chinese medicine IL-8 |
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