胃肠肽类激素与肠易激综合征发病间的关系

目的:研究肠易激综合征(IBS)患者血浆和乙状结肠黏膜组织中胃肠肽类激素的含量变化与肠易激综合征发病间的关系。方法:用放射免疫法分别检测IBS患者(40例)和正常对照组(15例)血浆及乙状结肠黏膜组织中胆囊收缩素(CCK)、血管活性肠肽(VIP)、生长抑素(SS)、P物质(SP)、酪神经肽(NPY)5种胃肠激素的含量。结果:①与正常对照组相比,IBS患者血浆中CCK含量明显升高(P<0.05),NPY含量减低(P<0.05),SS、VIP和SP含量变化差异无显著性(P>0.05)。②与正常对照组相比,IBS患者肠黏膜组织中VIP和SP含量均升高(P<0.01),NPY减低(P<0.05)而SS和CCK含量变化差异无显著性(P>0.05)。结论:IBS患者血浆或乙状结肠黏膜中CCK、VIP、SP、NPY的变化在IBS的发病中有一定的作用。

Relationship between Irritable Bowel Syndrome and Gastrointestinal Hormones

Objective: To investigate the alteration and clinical significance of cholecystokinin(CCK), vasoactive intestinal poly peptide( VIP), somatostatin (SS), substance P(SP), neuropeptide tyrosine(NPY) in irritable bowel syndrome (IBS). Methods: The CCK, VIP, SS, SP, NPY in plasma and sigmoid mucosa were measured by radioimmunoassay(RIA) in normal group( n = 15) and IBS group ( n =40). Results: The plasma CCK in IBS group was significandy higher than that in the normal group ( P < 0. 05), while there was no significant difference between two groups in the level of CCK of sigmoid mucosa ( P > 0. 05). The VIP and the SP of the sigmoid mucosa in IBS group were significandy higher than that in the normal group ( P < 0. 01), and diere was no significant differences between two groups in the plasma VIP and SP( P > 0. 05). The NPY of the plasma and sigmoid mucosa in IBS group was significandy lower than that in die normal group ( P < 0. 05). There was no significant difference between two groups in level of SS in plasma and sigmoid mucosa (P > 0. 05) . Conclusion: The alteration of diese gastrointestinal hormones in plasma and sigmoid mucosa may play some role in the pathogenesis of IBS.